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- W1511455087 abstract "1, 3-Dialkyl-6-hydrazinouracils (I) reacted with alkyl and acyl isothiocyanates to yield 5, 7-dialkyl-3-alkyl (or acyl) aminopyrazolo [3, 4-d] pyrimidine-4, 6 (5H, 7H)-diones (II). This reaction was investigated in detail and it was found that the first product was a 6-[4-alkyl (or acyl) thiosemicarbazido] uracil (IV), which cyclized to II through two pathways. Acylation of II afforded the corresponding 2-acyl derivatives. Treatment of 1, 3-diethyl-6-hydrazinouracil (Ia) with phosgeneimmonium chloride afforded 5, 7-diethyl-3-dimethylamino [3, 4-d] pyrimidine-4, 6 (5H, 7H)-dione (X)." @default.
- W1511455087 created "2016-06-24" @default.
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- W1511455087 date "1979-01-01" @default.
- W1511455087 modified "2023-09-23" @default.
- W1511455087 title "Fused pyrimidines. IV. Synthesis of 3-alkyl(or acyl)aminopyrazolo[3,4-d]pyrimidine derivatives from 6-hydrazinouracils and isothiocyanates." @default.
- W1511455087 doi "https://doi.org/10.1248/cpb.27.1328" @default.
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