FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1511492095> ?p ?o ?g. }

• W1511492095 abstract "Background: It has been hypothesized that stable mother rotors may increase the stability of atrial fibrillation. Local shortening of action potential duration due to vagotonic activity may promote the formation of mother rotors. However, prior studies have shown that meandering rotors typically drift out of the region of short action potential duration (APD), making the formation of stable rotors unlikely. Thus, for the formation of mother rotors in vagotonic AF a mechanism must be involved which increases rotor stability. Hypothesis: Local variation of electrotonic load due to branching muscle sleeves in the atrial tissue may avoid rotor drift and ease the formation of stable vagotonic AF. In this chapter the underlying mechanisms are illustrated by means of computer modeling. Model formulation: Anchoring is illustrated in a square patch of tissue and a monolayer model of the atria. Vagotonic activity was modeled by increasing ACh-concentration in the vicinity of the pulmonary veins (PVs). Close to the right lower PV, a muscle sleeve branching into the vein was included in the model. A model of canine atrial membrane kinetics was used providing detailed data on electrical remodeling and vagal activity. AF was analyzed computing dominant frequency (DF) maps and phase singularities (PSs). Model predictions: In the case of a missing anchor site AF was self terminating within 2 s of simulated activity. The rotor drifted out of the short APD region. After including a branching tissue structure, mother rotor formation was observed (anchoring and almost periodic activity over the entire simulated interval of 4.2 s). Pull and push currents were identified as the mechanism stabilizing the rotor trajectory. Push currents in the bundle reduced the DF at the branching by about 10%with respect to the highest DF (15 Hz). The computed DFmapmainly reflected the underlying ACh concentration (correlation 0.9). Summary: Branching tissue structures in regions of high ACh-concentration may constitute the substrate underlying vagotonic AF. Future experimental studies are needed to further confirm motor rotor anchoring in branching tissue." @default.
• W1511492095 created "2016-06-24" @default.
• W1511492095 creator A5039236966 @default.
• W1511492095 creator A5059954646 @default.
• W1511492095 creator A5074089712 @default.
• W1511492095 date "2012-01-11" @default.
• W1511492095 modified "2023-09-25" @default.
• W1511492095 title "Modeling Mother Rotor Anchoring in Branching Atrial Tissue" @default.
• W1511492095 cites W1971610775 @default.
• W1511492095 cites W1978815697 @default.
• W1511492095 cites W1991272252 @default.
• W1511492095 cites W1993015362 @default.
• W1511492095 cites W2017179259 @default.
• W1511492095 cites W2026610396 @default.
• W1511492095 cites W2028599309 @default.
• W1511492095 cites W2033891898 @default.
• W1511492095 cites W2038498445 @default.
• W1511492095 cites W2053844692 @default.
• W1511492095 cites W2062206620 @default.
• W1511492095 cites W2070702630 @default.
• W1511492095 cites W2079116530 @default.
• W1511492095 cites W2083327825 @default.
• W1511492095 cites W2104910523 @default.
• W1511492095 cites W2109944491 @default.
• W1511492095 cites W2110258428 @default.
• W1511492095 cites W2119650563 @default.
• W1511492095 cites W2139676847 @default.
• W1511492095 cites W2146673314 @default.
• W1511492095 cites W2149010016 @default.
• W1511492095 cites W2157313735 @default.
• W1511492095 cites W2167858546 @default.
• W1511492095 cites W2313203550 @default.
• W1511492095 cites W2341374042 @default.
• W1511492095 cites W2043583810 @default.
• W1511492095 doi "https://doi.org/10.5772/26884" @default.
• W1511492095 hasPublicationYear "2012" @default.
• W1511492095 type Work @default.
• W1511492095 sameAs 1511492095 @default.
• W1511492095 citedByCount "0" @default.
• W1511492095 crossrefType "book-chapter" @default.
• W1511492095 hasAuthorship W1511492095A5039236966 @default.
• W1511492095 hasAuthorship W1511492095A5059954646 @default.
• W1511492095 hasAuthorship W1511492095A5074089712 @default.
• W1511492095 hasBestOaLocation W15114920951 @default.
• W1511492095 hasConcept C127413603 @default.
• W1511492095 hasConcept C159985019 @default.
• W1511492095 hasConcept C17281054 @default.
• W1511492095 hasConcept C18483071 @default.
• W1511492095 hasConcept C192562407 @default.
• W1511492095 hasConcept C206175624 @default.
• W1511492095 hasConcept C66938386 @default.
• W1511492095 hasConcept C78519656 @default.
• W1511492095 hasConceptScore W1511492095C127413603 @default.
• W1511492095 hasConceptScore W1511492095C159985019 @default.
• W1511492095 hasConceptScore W1511492095C17281054 @default.
• W1511492095 hasConceptScore W1511492095C18483071 @default.
• W1511492095 hasConceptScore W1511492095C192562407 @default.
• W1511492095 hasConceptScore W1511492095C206175624 @default.
• W1511492095 hasConceptScore W1511492095C66938386 @default.
• W1511492095 hasConceptScore W1511492095C78519656 @default.
• W1511492095 hasLocation W15114920951 @default.
• W1511492095 hasLocation W15114920952 @default.
• W1511492095 hasOpenAccess W1511492095 @default.
• W1511492095 hasPrimaryLocation W15114920951 @default.
• W1511492095 hasRelatedWork W139177368 @default.
• W1511492095 hasRelatedWork W1511492095 @default.
• W1511492095 hasRelatedWork W1966101359 @default.
• W1511492095 hasRelatedWork W1972941541 @default.
• W1511492095 hasRelatedWork W2027634728 @default.
• W1511492095 hasRelatedWork W2029079666 @default.
• W1511492095 hasRelatedWork W2096473624 @default.
• W1511492095 hasRelatedWork W2565500163 @default.
• W1511492095 hasRelatedWork W4220653257 @default.
• W1511492095 hasRelatedWork W4237338679 @default.
• W1511492095 isParatext "false" @default.
• W1511492095 isRetracted "false" @default.
• W1511492095 magId "1511492095" @default.
• W1511492095 workType "book-chapter" @default.