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- W1511494417 abstract "Summary Background Drug‐induced liver injury may be immunologically mediated or metabolically induced. Peripheral eosinophilia and liver eosinophilia in suspected drug‐induced liver injury generally supports the role of drug aetiology. Aim To assess the importance of eosinophilia and hepatic necrosis on outcome in patients with suspected drug‐induced liver injury. Methods We performed search of MEDLINE for case reports on drug‐induced liver injury associated with: amoxicillin/clavulanic acid, carbamazepine, diclofenac, disulfiram, erythromycin, flucloxacillin, halothane, isoniazid, phenytoin, sulindac and trimethoprim/sulfametoxazol. Results A total of 570 case reports were retrieved. Mortality/transplantation occurred in 112 (20%). Eosinophilia in peripheral blood was reported in 34% of cases, eosinophilia in liver biopsies in 40%, and hepatic necrosis in 41%. Bilirubin levels were lower in patients with peripheral eosinophilia [5.5 × upper limit of normal (interquartile range 2.9–10) vs. 7.7 (4–17); P = 0.02] and patients with liver eosinophilia [5 × upper limit of normal (2.7–10) vs. 10 (5.4–20); P = 0.003] as compared with those without eosinophilia. Eosinophilia in peripheral blood and eosinophilia in liver biopsies were more common in patients who recovered (37% vs. 15.6%; P = 0.0001 and 48% vs. 18.8%; P < 0.0001, respectively). Hepatic necrosis was present in 24% in the survivors vs. 84% in non‐survivors ( P < 0.0001). Conclusions In drug‐induced liver injury, a favourable outcome was related to the occurrence of eosinophilia, whereas hepatic necrosis was associated with a poor prognosis." @default.
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- W1511494417 date "2007-04-06" @default.
- W1511494417 modified "2023-10-15" @default.
- W1511494417 title "The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury" @default.
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- W1511494417 doi "https://doi.org/10.1111/j.1365-2036.2007.03330.x" @default.
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