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- W1511700544 abstract "Lorazepam (Ativan) disposition and elimination were studied in 8 normal subjects before and after 1 wk of cimetidine therapy, 300 mg taken orally four times a day. In 4 of these 8 normal subjects the disposition and elimination of oxazepam (Serax) were also studied before and after similar treatment with cimetidine. Cimetidine did not alter the elimination of either lorazepam or oxazepam. Since both drugs are eliminated exclusively after conjugation as glucuronide, this study demonstrates a relative sparing of this pathway of biotransformation of drugs in subjects receiving cimetidine." @default.
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- W1511700544 date "1980-11-01" @default.
- W1511700544 modified "2023-09-27" @default.
- W1511700544 title "Cimetidine spares the glucuronidation of lorazepam and oxazepam" @default.
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- W1511700544 doi "https://doi.org/10.1016/0016-5085(80)90450-3" @default.
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