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- W1511714617 abstract "Abstract Beta 2-Microglobulin (beta 2m), a component of the major histocompatibility complex in chordates, has growth factor-like activity for cultured rat cells. We presently describe interactions between beta 2m and insulin-like growth factor I (IGF I) in osteoblast-enriched cultures. beta 2m increased DNA synthesis and was synergistic with IGF I. Affinity labeling revealed that beta 2m enhanced IGF I receptor number, and Northern analysis and radioimmunoassay showed that beta 2m increased steady state IGF I transcripts and medium IGF I polypeptide levels. These results indicate that the growth-promoting activity of beta 2m is mediated at least in part by regulating local IGF I binding and synthesis by skeletal cells." @default.
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- W1511714617 date "1989-11-01" @default.
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- W1511714617 title "β 2-microglobulin enhances insulin-like growth factor I receptor levels and synthesis in bone cell cultures" @default.
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- W1511714617 doi "https://doi.org/10.1016/s0021-9258(18)51456-3" @default.
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