FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1511759585> ?p ?o ?g. }

• W1511759585 endingPage "9" @default.
• W1511759585 startingPage "1" @default.
• W1511759585 abstract "Several lines of evidence suggest that astrocytes play a key role in modulating the immune responses of the central nervous system (CNS) to infections, injuries, or pathologies. Yet, their contribution to these processes remains mostly elusive. Astroglia are endowed with a wide range of toll-like receptors (TLR) by which they can sense infectious agents as well as endogenous danger signals released by damaged cells. Here we demonstrate that the activation of astrocytic TLR4 by bacterial lipopolysaccharide (LPS) challenge can promote nuclear factor κB (NF-κB)-dependent induction of pro-inflammatory and stress response mediators, particularly Tumor Necrosis Factor α (TNFα), cyclooxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS). Since the steroid lactone Withaferin A was described to inhibit NF-κB activity in different cell types, we next determined the impact of this natural compound towards the identified astrocytic signalling pathway. Innate immune activation was induced by stimulation of the LPS/TLR4 axis in spinal cord astrocytes. We provide evidence that both pre-treating and post-treating the cells with Withaferin A attenuate astrocytic NF-κB activity as well as the consequent production of TNFα, COX-2, and iNOS induced by stimulation of the LPS/TLR4 pathway. This study suggests that Withaferin A may be an eligible candidate for the treatment of neuroinflammatory and stress conditions characterized by an important astrocytic input." @default.
• W1511759585 created "2016-06-24" @default.
• W1511759585 creator A5005134485 @default.
• W1511759585 creator A5023413714 @default.
• W1511759585 creator A5040678382 @default.
• W1511759585 creator A5071586379 @default.
• W1511759585 date "2015-01-01" @default.
• W1511759585 modified "2023-10-12" @default.
• W1511759585 title "Withaferin A Inhibits Nuclear Factor-<i>κ</i>B-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes" @default.
• W1511759585 cites W1503511302 @default.
• W1511759585 cites W1522823711 @default.
• W1511759585 cites W1629086159 @default.
• W1511759585 cites W1639462457 @default.
• W1511759585 cites W1965942744 @default.
• W1511759585 cites W1972602040 @default.
• W1511759585 cites W1975110303 @default.
• W1511759585 cites W1978926805 @default.
• W1511759585 cites W1988726352 @default.
• W1511759585 cites W1990713194 @default.
• W1511759585 cites W1991063693 @default.
• W1511759585 cites W1993646281 @default.
• W1511759585 cites W1994640389 @default.
• W1511759585 cites W2004058448 @default.
• W1511759585 cites W2004937289 @default.
• W1511759585 cites W2011584176 @default.
• W1511759585 cites W2012017615 @default.
• W1511759585 cites W2019288170 @default.
• W1511759585 cites W2025796895 @default.
• W1511759585 cites W2029547213 @default.
• W1511759585 cites W2042095978 @default.
• W1511759585 cites W2047136145 @default.
• W1511759585 cites W2058623137 @default.
• W1511759585 cites W2058747197 @default.
• W1511759585 cites W2064874359 @default.
• W1511759585 cites W2064935465 @default.
• W1511759585 cites W2065021154 @default.
• W1511759585 cites W2066384268 @default.
• W1511759585 cites W2069513220 @default.
• W1511759585 cites W2079320514 @default.
• W1511759585 cites W2097465597 @default.
• W1511759585 cites W2103581491 @default.
• W1511759585 cites W2104767022 @default.
• W1511759585 cites W2105805458 @default.
• W1511759585 cites W2107587038 @default.
• W1511759585 cites W2110827592 @default.
• W1511759585 cites W2118236493 @default.
• W1511759585 cites W2121680389 @default.
• W1511759585 cites W2124851755 @default.
• W1511759585 cites W2127634810 @default.
• W1511759585 cites W2129319296 @default.
• W1511759585 cites W2144507462 @default.
• W1511759585 cites W2152098493 @default.
• W1511759585 cites W2157715974 @default.
• W1511759585 cites W2169073835 @default.
• W1511759585 cites W2038890616 @default.
• W1511759585 doi "https://doi.org/10.1155/2015/381964" @default.
• W1511759585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4523683" @default.
• W1511759585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26266054" @default.
• W1511759585 hasPublicationYear "2015" @default.
• W1511759585 type Work @default.
• W1511759585 sameAs 1511759585 @default.
• W1511759585 citedByCount "29" @default.
• W1511759585 countsByYear W15117595852016 @default.
• W1511759585 countsByYear W15117595852017 @default.
• W1511759585 countsByYear W15117595852018 @default.
• W1511759585 countsByYear W15117595852019 @default.
• W1511759585 countsByYear W15117595852020 @default.
• W1511759585 countsByYear W15117595852021 @default.
• W1511759585 countsByYear W15117595852022 @default.
• W1511759585 countsByYear W15117595852023 @default.
• W1511759585 crossrefType "journal-article" @default.
• W1511759585 hasAuthorship W1511759585A5005134485 @default.
• W1511759585 hasAuthorship W1511759585A5023413714 @default.
• W1511759585 hasAuthorship W1511759585A5040678382 @default.
• W1511759585 hasAuthorship W1511759585A5071586379 @default.
• W1511759585 hasBestOaLocation W15117595851 @default.
• W1511759585 hasConcept C134018914 @default.
• W1511759585 hasConcept C136449434 @default.
• W1511759585 hasConcept C142724271 @default.
• W1511759585 hasConcept C169760540 @default.
• W1511759585 hasConcept C17991360 @default.
• W1511759585 hasConcept C203014093 @default.
• W1511759585 hasConcept C204787440 @default.
• W1511759585 hasConcept C24998067 @default.
• W1511759585 hasConcept C2776070231 @default.
• W1511759585 hasConcept C2776598214 @default.
• W1511759585 hasConcept C2776914184 @default.
• W1511759585 hasConcept C2777542381 @default.
• W1511759585 hasConcept C2777622882 @default.
• W1511759585 hasConcept C2777730290 @default.
• W1511759585 hasConcept C2778754761 @default.
• W1511759585 hasConcept C2779830541 @default.
• W1511759585 hasConcept C2780069950 @default.
• W1511759585 hasConcept C519581460 @default.
• W1511759585 hasConcept C529278444 @default.
• W1511759585 hasConcept C62478195 @default.
• W1511759585 hasConcept C71924100 @default.
• W1511759585 hasConcept C86803240 @default.

• next