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• W1511823445 abstract "Epithelia of the vertebrate intestinal tract characteristically maintain an inflammatory hyporesponsiveness toward the lumenal prokaryotic microflora. We report the identification of enteric organisms (nonvirulent Salmonella strains) whose direct interaction with model human epithelia attenuate synthesis of inflammatory effector molecules elicited by diverse proinflammatory stimuli. This immunosuppressive effect involves inhibition of the inhibitor kappaB/nuclear factor kappaB (IkappaB/NF-kappaB) pathway by blockade of IkappaB-alpha degradation, which prevents subsequent nuclear translocation of active NF-kappaB dimer. Although phosphorylation of IkappaB-alpha occurs, subsequent polyubiquitination necessary for regulated IkappaB-alpha degradation is completely abrogated. These data suggest that prokaryotic determinants could be responsible for the unique tolerance of the gastrointestinal mucosa to proinflammatory stimuli." @default.
• W1511823445 created "2016-06-24" @default.
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• W1511823445 date "2000-09-01" @default.
• W1511823445 modified "2023-10-15" @default.
• W1511823445 title "Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination" @default.
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• W1511823445 doi "https://doi.org/10.1126/science.289.5484.1560" @default.
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