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• W1511892702 abstract "Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer worldwide. Two-thirds of affected patients present with advanced stage III or IV disease. Despite advances in combined modality therapy, involving surgery, radiotherapy, and chemotherapy, the 5-year survival rate remains at 40%. Concomitant external beam radiation and chemotherapy are more effective than radiotherapy alone. Nuclear medicine utilizes potential radiolabeled carriers in the diagnostics and therapy of cancer. Short-range Auger-electron emitters, such as In and In, tagged with a drug, molecule, peptide, protein, new class of trifunctional somatostatin analog or nanoparticles placed in close proximity to nuclear DNA represent a fascinating alternative for treating cancer. In this thesis, we studied the usefulness of In-BLMC in the diagnostics and potential therapy of HNSCC using in vitro HNSCC cell lines, in vivo nude mice, and in vivo HNSCC patients. In vitro experiments with HNSCC cell lines were performed using the 96-well plate clonogenic assay based on limited dilutions. The sensitivity for external beam radiation, BLM, In-BLMC, and InCl3 was studied using several HNSCC cell lines. The influence of BLM and In-BLMC on the cell cycle was investigated by flow cytometry. In in vivo nude mice xenograft studies, the activity ratios of In-BLMC were obtained in gamma camera images. Another purpose was to examine the effect of In-BLMC in HNSCC xenografts. In in vivo patient studies, we determined the tumor uptake of InBLMC by gamma camera and the radioactivity and proliferative activity from tumor samples using In-BLMC with specific activity of 75, 175, or 375 MBq/mg BLM. The S values, i.e. absorbed dose in a target organ/region per cumulated activity in a source organ/region, were simulated for In and In. In vitro studies expressed the variation of sensitivity for external beam radiation, BLM, and In-BLMC between HNSCC cell lines. IC50 values for BLM were 1.6-, 1.8-, and 2.1fold higher than In-BLMC (40 MBq/mg BLM) with three HNSCC cell lines. Specific In activity of 40 MBq/mg BLM was more effective in killing cells than specific In" @default.
• W1511892702 created "2016-06-24" @default.
• W1511892702 creator A5076798178 @default.
• W1511892702 date "2009-08-28" @default.
• W1511892702 modified "2023-10-17" @default.
• W1511892702 title "Auger-emitter radiochemotherapy in squamous cell cancers : in vitro and in vivo experiments with In-111-BLMC" @default.
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