FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1511897506> ?p ?o ?g. }

• W1511897506 endingPage "16613" @default.
• W1511897506 startingPage "16607" @default.
• W1511897506 abstract "Retinal rod outer segment phosphodiesterase (PDE) consists of two similar catalytic subunits (alpha and beta) and two identical inhibitory subunits (gamma 2). A trypsin-activated soluble PDE exhibiting the ability to be reinhibited by PDE gamma was shown by peptide antisera to retain both N and C termini. Synthetic peptides corresponding to residues 16-30, 78-90, 389-403, and 535-563 of PDE alpha used in a PDE activity assay with trypsin-activated PDE partially prevented inhibition by exogenous PDE gamma; however, only competitions by peptides 16-30 and 78-90 (corresponding to PDE alpha 16-30 and 78-90) were concentration-dependent below 100 nmol of peptide. Binding studies using radio-immunoassays and PDE alpha peptides confirmed that peptides 16-30 and 78-90 (corresponding to PDE alpha 16-30 and 78-90, respectively) were able to bind PDE gamma. Additionally, peptides corresponding to the PDE alpha region 453-534 bound PDE gamma in the binding assay. This suggests that several regions on PDE alpha interact with the PDE gamma inhibitor. While some regions may be involved in binding to PDE gamma, other sites may be involved in PDE gamma inhibition of catalytic activity. Our results suggest that the major regions of PDE alpha that interact with PDE gamma reside within the N terminus (16-30 and 78-90), with weaker interaction regions within or near the hypothesized catalytic domain (453-563). Sequence analysis of three retinal phosphodiesterases (rod outer segment alpha, beta, and cone outer segment alpha') revealed the highest region of dissimilarity in the N and C termini." @default.
• W1511897506 created "2016-06-24" @default.
• W1511897506 creator A5045039390 @default.
• W1511897506 creator A5047457848 @default.
• W1511897506 creator A5077786122 @default.
• W1511897506 creator A5079063332 @default.
• W1511897506 date "1991-09-01" @default.
• W1511897506 modified "2023-10-16" @default.
• W1511897506 title "Identification of the retinal cyclic GMP phosphodiesterase inhibitory gamma-subunit interaction sites on the catalytic alpha-subunit." @default.
• W1511897506 cites W111988334 @default.
• W1511897506 cites W1519694171 @default.
• W1511897506 cites W1543217424 @default.
• W1511897506 cites W1566243287 @default.
• W1511897506 cites W1570762629 @default.
• W1511897506 cites W1588399730 @default.
• W1511897506 cites W1969755572 @default.
• W1511897506 cites W1971168940 @default.
• W1511897506 cites W1971420793 @default.
• W1511897506 cites W1972031051 @default.
• W1511897506 cites W1973505127 @default.
• W1511897506 cites W1977118713 @default.
• W1511897506 cites W1982849102 @default.
• W1511897506 cites W2010358621 @default.
• W1511897506 cites W2012670429 @default.
• W1511897506 cites W2016542329 @default.
• W1511897506 cites W2020664801 @default.
• W1511897506 cites W2025364863 @default.
• W1511897506 cites W2029547503 @default.
• W1511897506 cites W2038825634 @default.
• W1511897506 cites W2046608233 @default.
• W1511897506 cites W2047404335 @default.
• W1511897506 cites W2062742450 @default.
• W1511897506 cites W2099375764 @default.
• W1511897506 cites W2100837269 @default.
• W1511897506 cites W2236349179 @default.
• W1511897506 cites W2320556745 @default.
• W1511897506 cites W2339346783 @default.
• W1511897506 cites W2922307617 @default.
• W1511897506 cites W4293247451 @default.
• W1511897506 cites W4320800855 @default.
• W1511897506 doi "https://doi.org/10.1016/s0021-9258(18)55344-8" @default.
• W1511897506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1653243" @default.
• W1511897506 hasPublicationYear "1991" @default.
• W1511897506 type Work @default.
• W1511897506 sameAs 1511897506 @default.
• W1511897506 citedByCount "21" @default.
• W1511897506 countsByYear W15118975062022 @default.
• W1511897506 crossrefType "journal-article" @default.
• W1511897506 hasAuthorship W1511897506A5045039390 @default.
• W1511897506 hasAuthorship W1511897506A5047457848 @default.
• W1511897506 hasAuthorship W1511897506A5077786122 @default.
• W1511897506 hasAuthorship W1511897506A5079063332 @default.
• W1511897506 hasBestOaLocation W15118975061 @default.
• W1511897506 hasConcept C104292427 @default.
• W1511897506 hasConcept C104317684 @default.
• W1511897506 hasConcept C116834253 @default.
• W1511897506 hasConcept C159110408 @default.
• W1511897506 hasConcept C161473406 @default.
• W1511897506 hasConcept C164083038 @default.
• W1511897506 hasConcept C169760540 @default.
• W1511897506 hasConcept C17077164 @default.
• W1511897506 hasConcept C181199279 @default.
• W1511897506 hasConcept C185592680 @default.
• W1511897506 hasConcept C2775944032 @default.
• W1511897506 hasConcept C2780827179 @default.
• W1511897506 hasConcept C2910882050 @default.
• W1511897506 hasConcept C3020139451 @default.
• W1511897506 hasConcept C49453240 @default.
• W1511897506 hasConcept C55493867 @default.
• W1511897506 hasConcept C59822182 @default.
• W1511897506 hasConcept C62826618 @default.
• W1511897506 hasConcept C64943373 @default.
• W1511897506 hasConcept C71924100 @default.
• W1511897506 hasConcept C83730767 @default.
• W1511897506 hasConcept C86803240 @default.
• W1511897506 hasConceptScore W1511897506C104292427 @default.
• W1511897506 hasConceptScore W1511897506C104317684 @default.
• W1511897506 hasConceptScore W1511897506C116834253 @default.
• W1511897506 hasConceptScore W1511897506C159110408 @default.
• W1511897506 hasConceptScore W1511897506C161473406 @default.
• W1511897506 hasConceptScore W1511897506C164083038 @default.
• W1511897506 hasConceptScore W1511897506C169760540 @default.
• W1511897506 hasConceptScore W1511897506C17077164 @default.
• W1511897506 hasConceptScore W1511897506C181199279 @default.
• W1511897506 hasConceptScore W1511897506C185592680 @default.
• W1511897506 hasConceptScore W1511897506C2775944032 @default.
• W1511897506 hasConceptScore W1511897506C2780827179 @default.
• W1511897506 hasConceptScore W1511897506C2910882050 @default.
• W1511897506 hasConceptScore W1511897506C3020139451 @default.
• W1511897506 hasConceptScore W1511897506C49453240 @default.
• W1511897506 hasConceptScore W1511897506C55493867 @default.
• W1511897506 hasConceptScore W1511897506C59822182 @default.
• W1511897506 hasConceptScore W1511897506C62826618 @default.
• W1511897506 hasConceptScore W1511897506C64943373 @default.
• W1511897506 hasConceptScore W1511897506C71924100 @default.
• W1511897506 hasConceptScore W1511897506C83730767 @default.
• W1511897506 hasConceptScore W1511897506C86803240 @default.
• W1511897506 hasIssue "25" @default.

• next