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• W1512073315 abstract "The endothelium, the innermost layer of blood vessels, has many important biological functions which are responsible for regulating vascular tone and structure. One of the major functions of a healthy endothelium is to ensure adequate blood supply to the different tissues. This particular process is regulated by the release and interaction of different vasoactive substances (i.e. vasodilators and vasoconstrictors), which are under tight balance. On the other hand, it is well known that the chronic exposure to certain stresses (e.g. inflammation, oxidative stress, and hyperglycemia) promotes changes in the endothelium leading to endothelial dysfunction. Type 2 diabetes mellitus (T2DM) is among those chronic diseases that are associated with endothelial dysfunction which may contribute to limited glucose uptake in skeletal muscle. In fact, diabetes-related endothelial dysfunction has been reported to lead to morphologic and structural vascular changes present throughout the course of diabetes (Taylor and Poston, 1994). There are around 17 million people in the United States who have diabetes, of whom close to 95% have T2DM. Cardiovascular disease (CVD) is the major cause of morbidity and mortality in people with T2DM (Ness et al., 1999), and coronary heart disease is the most common cause of death among those individuals. For instance, people with T2DM are two to four times more likely to develop CVD compared with people without the condition (Stamler et al., 1993). Interestingly, physical activity is an important therapeutic tool to maintain endothelial function. In fact, regular physical exercise has been reported to be effective in the prevention and delay of onset of T2DM (Bassuk and Manson, 2005; Sanz et al., 2010; Stewart, 2002). Thus the primary purpose of this chapter is to summarize the current available literature concerning the effects of T2DM on arterial endothelium. In addition, this chapter is intended to summarize evidence of the beneficial effects of physical activity on the untoward cardiovascular effects of T2DM and/or the apparent ability of physical activity to prevent progression of diabetes-induced CVD." @default.
• W1512073315 created "2016-06-24" @default.
• W1512073315 creator A5037673510 @default.
• W1512073315 creator A5039035403 @default.
• W1512073315 creator A5070390150 @default.
• W1512073315 date "2011-08-29" @default.
• W1512073315 modified "2023-10-03" @default.
• W1512073315 title "Effects of Type 2 Diabetes on Arterial Endothelium" @default.
• W1512073315 cites W106337374 @default.
• W1512073315 cites W134737704 @default.
• W1512073315 cites W1484535674 @default.
• W1512073315 cites W1546802604 @default.
• W1512073315 cites W1557753272 @default.
• W1512073315 cites W1571495789 @default.
• W1512073315 cites W1619653867 @default.
• W1512073315 cites W1834350010 @default.
• W1512073315 cites W1845594264 @default.
• W1512073315 cites W1846153624 @default.
• W1512073315 cites W1928175618 @default.
• W1512073315 cites W1965171075 @default.
• W1512073315 cites W1965287127 @default.
• W1512073315 cites W1966160078 @default.
• W1512073315 cites W1967265218 @default.
• W1512073315 cites W1967899379 @default.
• W1512073315 cites W1969003820 @default.
• W1512073315 cites W1969300883 @default.
• W1512073315 cites W1973479401 @default.
• W1512073315 cites W1975830045 @default.
• W1512073315 cites W1977011452 @default.
• W1512073315 cites W1979598489 @default.
• W1512073315 cites W1980445357 @default.
• W1512073315 cites W1980967170 @default.
• W1512073315 cites W1982135265 @default.
• W1512073315 cites W1984026469 @default.
• W1512073315 cites W1985399016 @default.
• W1512073315 cites W1991500123 @default.
• W1512073315 cites W1993387626 @default.
• W1512073315 cites W1993616653 @default.
• W1512073315 cites W1994950364 @default.
• W1512073315 cites W1995800794 @default.
• W1512073315 cites W1996564597 @default.
• W1512073315 cites W2001657480 @default.
• W1512073315 cites W2003822516 @default.
• W1512073315 cites W2003929217 @default.
• W1512073315 cites W2005262235 @default.
• W1512073315 cites W2006405826 @default.
• W1512073315 cites W2006990802 @default.
• W1512073315 cites W2007737411 @default.
• W1512073315 cites W2009705987 @default.
• W1512073315 cites W2011090923 @default.
• W1512073315 cites W2011677357 @default.
• W1512073315 cites W2012767083 @default.
• W1512073315 cites W2013529909 @default.
• W1512073315 cites W2014759828 @default.
• W1512073315 cites W2014946284 @default.
• W1512073315 cites W2015807898 @default.
• W1512073315 cites W2019437972 @default.
• W1512073315 cites W2022709209 @default.
• W1512073315 cites W2024144186 @default.
• W1512073315 cites W2024435928 @default.
• W1512073315 cites W2025870581 @default.
• W1512073315 cites W2026157289 @default.
• W1512073315 cites W2027887123 @default.
• W1512073315 cites W2029494697 @default.
• W1512073315 cites W2029891724 @default.
• W1512073315 cites W2032786707 @default.
• W1512073315 cites W2033525828 @default.
• W1512073315 cites W2033655946 @default.
• W1512073315 cites W2037507338 @default.
• W1512073315 cites W2039104615 @default.
• W1512073315 cites W2039420330 @default.
• W1512073315 cites W2039606602 @default.
• W1512073315 cites W2040445576 @default.
• W1512073315 cites W2040935694 @default.
• W1512073315 cites W2041156347 @default.
• W1512073315 cites W2042008548 @default.
• W1512073315 cites W2042287404 @default.
• W1512073315 cites W2043792354 @default.
• W1512073315 cites W2043810849 @default.
• W1512073315 cites W2044193679 @default.
• W1512073315 cites W2044460082 @default.
• W1512073315 cites W2048635427 @default.
• W1512073315 cites W2055689111 @default.
• W1512073315 cites W2059052527 @default.
• W1512073315 cites W2060449981 @default.
• W1512073315 cites W2060481174 @default.
• W1512073315 cites W2062281472 @default.
• W1512073315 cites W2062868044 @default.
• W1512073315 cites W2063223047 @default.
• W1512073315 cites W2064068403 @default.
• W1512073315 cites W2065111656 @default.
• W1512073315 cites W2066534940 @default.
• W1512073315 cites W2066992591 @default.
• W1512073315 cites W2067514854 @default.
• W1512073315 cites W2072219150 @default.
• W1512073315 cites W2073760318 @default.
• W1512073315 cites W2074390557 @default.
• W1512073315 cites W2074481216 @default.
• W1512073315 cites W2075039458 @default.
• W1512073315 cites W2076215026 @default.

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