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• W1512156936 abstract "Methods are described for the production of vesicular stomatitis (VS) virus of sufficient purity for reliable chemical analysis. VS virions released from infected cells were concentrated and purified at least 150-fold by sequential steps of precipitation with polyethylene glycol, column chromatography, rate zonal centrifugation, and equilibrium centrifugation. The Indiana serotype (VS Ind virus) propagated in L-cells was found to contain 3% ribonucleic acid, 64% protein, 13% carbohydrate, and 20% lipid; the molar ratio of cholesterol to phospholipid was 0.6 or greater. Thin-layer chromatography revealed no unusual neutral lipids or phospholipids and gas-liquid chromatography revealed no unusual fatty acids incorporated into VS virions. The antigenically distinct New Jersey serotype (VS NJ virus) grown in L-cells showed a similar lipid profile except that the proportion of neutral lipids was larger than in VS Ind virus also grown in L-cells. This differences was less pronounced when the lipid composition of VS Ind and VS NJ viruses grown in chick embryo cells was compared, but VS NJ virus grown in either cell type always contained larger amounts of neutral lipids other than cholesterol than did VS Ind virus. The lipid composition of both VS Ind and VS NJ viruses grown in L-cells or chick embryo cells more closely resembled that of plasma membrane than of whole cells. A consistent finding was the relatively large amounts of phosphatidylethanolamine and sphingomyelin and the relatively small amounts of phosphatidylcholine in both VS viruses compared with uninfected whole L-cells and chick embryo cells or their plasma membranes. The methods available for isolation of plasma membranes were inadequate for conclusive comparison of the lipids of VS virions with the lipids of the plasma membranes of their host cells. Nevertheless, the data obtained are consistent with two hypotheses: (i) the lipid composition of VS viruses primarily reflects their membrane site of maturation, and (ii) the newly synthesized viral proteins inserted into cell membranes influence the proportions of phospholipids and neutral lipids selected for incorporation into the viral membrane." @default.
• W1512156936 created "2016-06-24" @default.
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• W1512156936 date "1971-01-01" @default.
• W1512156936 modified "2023-10-17" @default.
• W1512156936 title "Lipid Composition of Purified Vesicular Stomatitis Viruses" @default.
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• W1512156936 doi "https://doi.org/10.1128/jvi.7.1.59-70.1971" @default.
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