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- W1512266612 abstract "The 110-kDa intracellular phosphoprotein (110K) described previously by this laboratory as a common IgM autoantigen in SLE and certain other systemic autoimmune disorders and viral infections is identified as nucleolin in the present investigation. Using rabbit antiserum to rat nucleolin as a probe, IgM autoantibody-reactive 110K co-migrated with human lymphocyte nucleolin in one- and two-dimensional immunoblots. Rabbit anti-nucleolin also specifically depleted autoreactive 110K from detergent lysates of human cells. Because nucleolin shares amino acid sequence similarity and/or forms dynamic particles with other prominent autoantigens, the present observation raises the possibility that the nucleolin/anti-nucleolin system may be of special significance for the development of humoral autoreactivity to nuclear Ag." @default.
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- W1512266612 date "1991-04-01" @default.
- W1512266612 modified "2023-10-14" @default.
- W1512266612 title "Autoantibodies to nucleolin in systemic lupus erythematosus and other diseases." @default.
- W1512266612 doi "https://doi.org/10.4049/jimmunol.146.7.2249" @default.
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