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- W1512421617 abstract "I N 1951, Richardson1 published a new biochemical test for pregnanW. Earl!results showed an accuracy approaching 100 per cent in known pregnancies. But the test was also positive in 50 per cent of the nonpregnant individuals. Further studies demonst,rated the fact that two endocrine factors wtbre the sources of the positive responses in the nonpregnant women. Richardson then developed an estractive met,hod by which the interfering agents could be removed and was able to obtain approximately 100 per cent. accuracp in both groups. The product of pregnancy whic*h is identified by this is free e&one. Although present in nonpregnant women, its 11ornial concentration is insufficient to give a positive reaction except in pregnancy. hydatidiform Inolc, and chorionepithclioma. The latter two, howcvcr, J.O~~UW a positive reaction even in highly diluted urine. Rapp and Richardson” investigated this test further and, in 1952, concluded t,hat the reaction depends on the presence of free cstrone in contrast to bound or modified estrone, or similar 3’i-ketost.eroids. The free csbrone level was found to increase markedly after conception so t,hat ljositire reactions were obtained two weeks after fertilization and even before amenorrhea occurred. In his original article, Richardson reported tests on such fluids as saliva, tears, and sweat, as well as blood and urine. While the test on urine was positive in all wolnen jn the sixth or seventh mont.h of pregnancy, it was negative in some oI’ these when the saliva was tested. This lack of correlation was understandal)le after the birth of t,he child. It was found that in nearly every case where the> saliva test, proved JWsitivc, a" @default.
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- W1512421617 date "1954-05-01" @default.
- W1512421617 modified "2023-09-27" @default.
- W1512421617 title "Sex prediction through the use of maternal saliva" @default.
- W1512421617 cites W1577309026 @default.
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- W1512421617 doi "https://doi.org/10.1016/0002-9378(54)90266-5" @default.
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