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• W1512432351 abstract "Legionella pneumophila is an inhabitant of the aquatic environment and the causative agent of a bacterial pneumonia. We identified the presence of an L. pneumophila homologue of csrA of E. coli and rsmA of Erwinia carotovora, genes which regulate gene expression by destabilising mRNA and which have been shown to relate to environmental fitness and pathogenicity. The Legionella csrA was able to complement a csrA-negative mutant of E. coli. Overproduction of csrA in L. pneumophila lead to a reduction of flagellation and pigmentation and an increase in bacterial cell size. csrA overproduction was associated with a reduction of fliA and flaA transcripts. This suggests that similar to E. coli and Erwinia, L. pneumophila csrA is a regulator of gene expression and may contribute to the capability of the pathogen to rapidly adapt to changing environments." @default.
• W1512432351 created "2016-06-24" @default.
• W1512432351 creator A5021299894 @default.
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• W1512432351 creator A5031911139 @default.
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• W1512432351 date "2001-01-01" @default.
• W1512432351 modified "2023-09-25" @default.
• W1512432351 title "Overexpresssion of a homologue of the regulator affects cell size, flagellation, and pigmentation" @default.
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• W1512432351 doi "https://doi.org/10.1078/1438-4221-00141" @default.
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