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- W1512551330 abstract "The complete κ-chain variable region sequences from two murine myeloma proteins (U-61 and E-109) with binding specificity for β(2-1) fructofuranosyl moieties have been determined. The two κ-chains differ from each other by four amino acids. Earlier studies with recombinant molecules have assigned three different idiotypes to these two light chains. One of these determinants is hapten inhibitable and is presumed to be in or near the combining site, whereas the remaining two are not hapten inhibitable. Analysis of the four sequence differences found between these two chains in conjunction with a hypothetical three-dimensional model of the anti-fructan antibodies reveals that the hapten-inhibitable idiotype appears to be determined by the association of two amino acids found in complementarity-determining regions I and III. One of the nonhapten-inhibitable determinants could be caused by any of the three substitutions occurring in the framework portion of the variable region. The second of these determinants appears to result from the three-dimensional proximity of more than one framework amino acid.A comparison of the U-61 and E-109 structures with partial sequences from several other light chains from fructofuranose-binding proteins revealed a total of eight differences occurring both in framework and complementarity-determining regions. The identification of Ser in two proteins at residue 30 and Asn at this position in three other proteins suggests that despite the great degree of homology exhibited by these light chains at least two germline genes would be required to code for these molecules." @default.
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- W1512551330 date "1979-05-01" @default.
- W1512551330 modified "2023-09-23" @default.
- W1512551330 title "The structural basis of a hapten-inhibitable kappa-chain idiotype." @default.
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