Matches in SemOpenAlex for { <https://semopenalex.org/work/W1512561574> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1512561574 endingPage "13" @default.
- W1512561574 startingPage "1301" @default.
- W1512561574 abstract "Immune responses in thymus derived (T) cell-depleted mouse spleen cultures were stimulated by the addition of either syngeneic T cells immunized with antigen, or allogeneic T cells reactive against precursor antibody-forming cells. Both require the presence of specific antigen in cultures. At low T cell concentrations, ( 6 ), allogeneic T cells are more effective in stimulating immune responses than the syngeneic T cells, however, at higher cell numbers (> 10 6 ), allogeneic T cells suppress the response. The stimulation of in vitro immune responses to heterologous erythrocyte antigens is mediated by nonspecific activity released from antigen-stimulated T cells in culture supernatants. Fractionation of culture supernatants prepared in serum-free media, by Sephadex G-100 chromatography, revealed the presence of three thymus cell-replacing factors (TRF). The fractionation profiles of supernatant activities prepared from syngeneic and allogeneic T cells were identical. TRF-I from both T cell sources has a molecular weight around 150,000, is labile to heat, periodate, and trypsin, and requires the presence of θ-positive cells for production in culture. TRF-I does not appear to be immunoglobulin in nature. TRF-II (m.w. 15,000 to 40,000), and TRF-III (m.w." @default.
- W1512561574 created "2016-06-24" @default.
- W1512561574 creator A5036761166 @default.
- W1512561574 date "1973-11-01" @default.
- W1512561574 modified "2023-10-03" @default.
- W1512561574 title "The role of humoral factors in the initiation of in vitro primary immune responses. 3. Characterization of factors that replace thymus-derived cells." @default.
- W1512561574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4542808" @default.
- W1512561574 hasPublicationYear "1973" @default.
- W1512561574 type Work @default.
- W1512561574 sameAs 1512561574 @default.
- W1512561574 citedByCount "32" @default.
- W1512561574 countsByYear W15125615742014 @default.
- W1512561574 crossrefType "journal-article" @default.
- W1512561574 hasAuthorship W1512561574A5036761166 @default.
- W1512561574 hasConcept C104317684 @default.
- W1512561574 hasConcept C145558887 @default.
- W1512561574 hasConcept C147483822 @default.
- W1512561574 hasConcept C153911025 @default.
- W1512561574 hasConcept C154317977 @default.
- W1512561574 hasConcept C159654299 @default.
- W1512561574 hasConcept C163994747 @default.
- W1512561574 hasConcept C181199279 @default.
- W1512561574 hasConcept C202751555 @default.
- W1512561574 hasConcept C203014093 @default.
- W1512561574 hasConcept C2776090121 @default.
- W1512561574 hasConcept C2780115692 @default.
- W1512561574 hasConcept C49382859 @default.
- W1512561574 hasConcept C55493867 @default.
- W1512561574 hasConcept C67662055 @default.
- W1512561574 hasConcept C86803240 @default.
- W1512561574 hasConcept C8891405 @default.
- W1512561574 hasConceptScore W1512561574C104317684 @default.
- W1512561574 hasConceptScore W1512561574C145558887 @default.
- W1512561574 hasConceptScore W1512561574C147483822 @default.
- W1512561574 hasConceptScore W1512561574C153911025 @default.
- W1512561574 hasConceptScore W1512561574C154317977 @default.
- W1512561574 hasConceptScore W1512561574C159654299 @default.
- W1512561574 hasConceptScore W1512561574C163994747 @default.
- W1512561574 hasConceptScore W1512561574C181199279 @default.
- W1512561574 hasConceptScore W1512561574C202751555 @default.
- W1512561574 hasConceptScore W1512561574C203014093 @default.
- W1512561574 hasConceptScore W1512561574C2776090121 @default.
- W1512561574 hasConceptScore W1512561574C2780115692 @default.
- W1512561574 hasConceptScore W1512561574C49382859 @default.
- W1512561574 hasConceptScore W1512561574C55493867 @default.
- W1512561574 hasConceptScore W1512561574C67662055 @default.
- W1512561574 hasConceptScore W1512561574C86803240 @default.
- W1512561574 hasConceptScore W1512561574C8891405 @default.
- W1512561574 hasIssue "5" @default.
- W1512561574 hasLocation W15125615741 @default.
- W1512561574 hasOpenAccess W1512561574 @default.
- W1512561574 hasPrimaryLocation W15125615741 @default.
- W1512561574 hasRelatedWork W1916124589 @default.
- W1512561574 hasRelatedWork W1964007185 @default.
- W1512561574 hasRelatedWork W2026429915 @default.
- W1512561574 hasRelatedWork W2033530968 @default.
- W1512561574 hasRelatedWork W2039225897 @default.
- W1512561574 hasRelatedWork W2088253473 @default.
- W1512561574 hasRelatedWork W2379761520 @default.
- W1512561574 hasRelatedWork W3007075535 @default.
- W1512561574 hasRelatedWork W3031852375 @default.
- W1512561574 hasRelatedWork W3112940496 @default.
- W1512561574 hasVolume "111" @default.
- W1512561574 isParatext "false" @default.
- W1512561574 isRetracted "false" @default.
- W1512561574 magId "1512561574" @default.
- W1512561574 workType "article" @default.