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- W151257593 abstract "Recent market withdrawals of prescription drug products have brought attention to premarketing safety research. Less known but related to some drug withdrawals are postmarketing dosage changes of newly marketed drugs, including both dosage reductions and increases. These events have serious effects on patients, manufacturers, and regulatory authorities. Most of these harmful events could be avoided by intensive employment of targeted clinical pharmacology investigations to optimize dosage prior to phase III testing and regulatory approval. In this paper, the frequency and implications of postmarketing dosing changes and market withdrawals are considered in light of approaches to preventing them." @default.
- W151257593 created "2016-06-24" @default.
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- W151257593 date "2007-03-01" @default.
- W151257593 modified "2023-09-25" @default.
- W151257593 title "Preventing Postmarketing Changes in Recommended Doses and Marketing Withdrawals" @default.
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- W151257593 doi "https://doi.org/10.1007/978-3-540-49529-1_16" @default.
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