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• W1512615057 abstract "ABSTRACT Vanadium toxicity is a challenging problem to human and animal health with no entirely understanding cytotoxic mechanisms. Previous studies in vanadium toxicity showed involvement of oxidative stress in isolated liver hepatocytes and mitochondria via increasing of ROS formation, release of cytochrome c and ATP depletion after incubation with different concentrations (25–200 µ M ). Therefore, we aimed to investigate the protective effects of Sesamum indicum seed extract (100–300 μg/mL) against oxidative stress induced by vanadium on isolated rat hepatocytes. Our results showed that quite similar to Alpha‐tocopherol (100 µ M ), different concentrations of extract (100–300 μg/mL) protected the isolated hepatocyte against all oxidative stress/cytotoxicity markers induced by vanadium in including cell lysis, ROS generation, mitochondrial membrane potential decrease and lysosomal membrane damage. Besides, vanadium induced mitochondrial/lysosomal toxic interaction and vanadium reductive activation mediated by glutathione in vanadium toxicity was significantly ( P < 0.05) ameliorated by Sesamum indicum extracts. These findings suggested a hepato‐protective role for extracts against liver injury resulted from vanadium toxicity. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 979–985, 2016." @default.
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• W1512615057 date "2015-03-02" @default.
• W1512615057 modified "2023-10-14" @default.
• W1512615057 title "Protective effects of <scp><i>S</i></scp><i>esamum indicum</i> extract against oxidative stress induced by vanadium on isolated rat hepatocytes" @default.
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• W1512615057 doi "https://doi.org/10.1002/tox.22107" @default.
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