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• W1512697811 startingPage "1060" @default.
• W1512697811 abstract "The ultimate goal of therapeutic vaccines is to activate and exploit the patient's own immune system to vigorously and dynamically seek and eradicate established malignant or virally infected cells. Therapeutic vaccines also offer the potential for preventing disease recurrence. Saccharomyces cerevisiae-based vaccines, where the yeast is engineered to express viral or tumor antigens, represent an ideal therapeutic approach due to their ability to stimulate tumor- or viral-specific CD4+ and CD8+ T-cell responses that are capable of reducing disease burden. This review describes preclinical and clinical studies supporting the development of S. cerevisiae-based therapeutic vaccines for the treatment of cancer and viral diseases, as well as multimodal strategies in which therapeutic vaccines are combined with cytotoxic drugs to achieve a greater clinical response." @default.
• W1512697811 created "2016-06-24" @default.
• W1512697811 creator A5003174995 @default.
• W1512697811 creator A5016328953 @default.
• W1512697811 creator A5074905192 @default.
• W1512697811 date "2010-11-05" @default.
• W1512697811 modified "2023-10-06" @default.
• W1512697811 title "Vaccines based on whole recombinant Saccharomyces cerevisiae cells" @default.
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• W1512697811 doi "https://doi.org/10.1111/j.1567-1364.2010.00665.x" @default.
• W1512697811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7295092" @default.
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