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• W1512717099 abstract "Single channel properties of Ca 2+ ‐activated K + (BK or Maxi‐K) channels have been investigated in presynaptic membranes in Xenopus motoneurone–muscle cell cultures. The occurrence and density of BK channels increased with maturation/synaptogenesis and was not uniform: highest at the release face of bouton‐like synaptic varicosities in contact with muscle cells, and lowest in varicosities that did not contact muscle cells. The Ca 2+ affinity of the channel ( K d = 7.7 μ m at a membrane potential of +20 mV) was lower than those of BK channels that have been characterized in other terminals. Hill coefficients varied between 1.5 and 2.8 at different potentials and open probability increased e‐fold per 16 mV change in membrane potential over a range of [Ca 2+ ] i from 1 μ m to 1 m m . The maximal activation rate of ensembled single BK channel currents was in the submillisecond range at ≥+20 mV. The activation rate increased ∼10‐fold in response to a [Ca 2+ ] i increase from 1 to 100 μ m , but increased only ∼2‐fold with a voltage change from +20 to +130 mV. The fastest activation kinetics of BK channels in cell‐attached patches resembled that in inside‐out patches with [Ca 2+ ] i of 100 μ m or more, suggesting that many BK channels are located very close to calcium channels. Given the low Ca 2+ affinity and rapid Ca 2+ binding/unbinding properties, we conclude that BK channels in this preparation are adapted to play an important role in regulation of neurotransmitter release, and they are ideal reporters of local [Ca 2+ ] at the inner membrane surface." @default.
• W1512717099 created "2016-06-24" @default.
• W1512717099 creator A5035662975 @default.
• W1512717099 creator A5047830707 @default.
• W1512717099 creator A5075938431 @default.
• W1512717099 date "2004-05-01" @default.
• W1512717099 modified "2023-10-18" @default.
• W1512717099 title "Electrophysiological properties of BK channels in <i>Xenopus</i> motor nerve terminals" @default.
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• W1512717099 doi "https://doi.org/10.1113/jphysiol.2003.060509" @default.
• W1512717099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1665056" @default.
• W1512717099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15047773" @default.
• W1512717099 hasPublicationYear "2004" @default.
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