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- W1512743967 abstract "Tan, W. C. (Dept. of Biochemistry, Indiana U., School of Medicine, Indianapolis, Indiana, U.S.A. ) , and Bernard Malin. Biosynthesis of Glutamic Acid. Butler U. Bot. Studies 14(2) : 89-103. 1964. An unknown microorganism was isolated from the soil by using defined selective medium. It could synthesize glutamic acid from glucose and urea. When subjected to repeated ultra-violet light and X-ray irradiations, and after process of screening, the organism had increased the yield of glutamic acid biosynthesis up to 10 mgm per ml of broth. The pathway of glutamic acid biosynthesis is unknown. Evidences indicated that the TCA cycle was probably not involved. The microorganism could be a new species of Micrococcus. Glutamic acid may be produced either by chemical or fermentation method. By the chemical method, hydrolyzed protein such as soybean cake or wheat gluten is used. However, the product obtained is always in the DL-form or racemic form. Separation of the D and L forms is not only difficult but also time consuming and expensive. On the other hand, biosynthesis of glutamic acid yields exclusively the L form. A few microorganisms are known to possess this biosynthetic ability (1). All of these microorganisms have been isolated by the fermentation industry companies in Japan. The method of isolation has not been revealed. It is known that only after long years of research a strain which can synthesize glutamic acid was obtained. Glutamic acid is an important flavoring agent which has the largest commercial demand among the various amino acids (2). Therefore special effort has been devoted to the production of L-glutamic acid especially by fermentation method which is now on a commercial scale. Many microorganisms can synthesize various amino acids in small amounts in culture media. But to obtain a particular organism which can produce" @default.
- W1512743967 created "2016-06-24" @default.
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- W1512743967 date "1964-01-01" @default.
- W1512743967 modified "2023-09-28" @default.
- W1512743967 title "BIOSYNTHESIS OF GLUTAMIC ACID" @default.
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