Matches in SemOpenAlex for { <https://semopenalex.org/work/W1512758510> ?p ?o ?g. }
- W1512758510 endingPage "500" @default.
- W1512758510 startingPage "479" @default.
- W1512758510 abstract "Type 2 diabetes mellitus (T2D) arises when the endocrine pancreas fails to secrete sufficient insulin to cope with the metabolic demand because of beta-cell secretory dysfunction and/or decreased beta-cell mass. Defining the nature of the pancreatic islet defects present in T2D has been difficult, in part because human islets are inaccessible for direct study. This review is aimed to illustrate to what extent the Goto-Kakizaki rat, one of the best characterized animal models of spontaneous T2D, has proved to be a valuable tool offering sufficient commonalities to study this aspect. A comprehensive compendium of the multiple functional GK islet abnormalities so far identified is proposed in this perspective. The pathogenesis of defective beta-cell number and function in the GK model is also discussed. It is proposed that the development of T2D in the GK model results from the complex interaction of multiple events: (i) several susceptibility loci containing genes responsible for some diabetic traits (distinct loci encoding impairment of beta-cell metabolism and insulin exocytosis, but no quantitative trait locus for decreased beta-cell mass); (ii) gestational metabolic impairment inducing an epigenetic programming of the offspring pancreas (decreased beta-cell neogenesis and proliferation) transmitted over generations; and (iii) loss of beta-cell differentiation related to chronic exposure to hyperglycaemia/hyperlipidaemia, islet inflammation, islet oxidative stress, islet fibrosis and perturbed islet vasculature." @default.
- W1512758510 created "2016-06-24" @default.
- W1512758510 creator A5001460699 @default.
- W1512758510 creator A5009546656 @default.
- W1512758510 creator A5019096836 @default.
- W1512758510 creator A5024894347 @default.
- W1512758510 creator A5033730694 @default.
- W1512758510 creator A5037054258 @default.
- W1512758510 creator A5041874198 @default.
- W1512758510 creator A5042726229 @default.
- W1512758510 creator A5060578359 @default.
- W1512758510 creator A5063179478 @default.
- W1512758510 creator A5090595473 @default.
- W1512758510 date "2010-01-01" @default.
- W1512758510 modified "2023-10-06" @default.
- W1512758510 title "Islet Structure and Function in the GK Rat" @default.
- W1512758510 cites W1516670301 @default.
- W1512758510 cites W1541633820 @default.
- W1512758510 cites W1964127642 @default.
- W1512758510 cites W1965141016 @default.
- W1512758510 cites W1966650637 @default.
- W1512758510 cites W1968488515 @default.
- W1512758510 cites W1968967036 @default.
- W1512758510 cites W1970437660 @default.
- W1512758510 cites W1971851312 @default.
- W1512758510 cites W1973432554 @default.
- W1512758510 cites W1985938279 @default.
- W1512758510 cites W1991694020 @default.
- W1512758510 cites W1994026558 @default.
- W1512758510 cites W1994481196 @default.
- W1512758510 cites W1994892275 @default.
- W1512758510 cites W1994914276 @default.
- W1512758510 cites W1998308514 @default.
- W1512758510 cites W1998413855 @default.
- W1512758510 cites W2003012462 @default.
- W1512758510 cites W2003252351 @default.
- W1512758510 cites W2003309743 @default.
- W1512758510 cites W2004536780 @default.
- W1512758510 cites W2005635904 @default.
- W1512758510 cites W2009273466 @default.
- W1512758510 cites W2009320519 @default.
- W1512758510 cites W2010064539 @default.
- W1512758510 cites W2016248443 @default.
- W1512758510 cites W2017819494 @default.
- W1512758510 cites W2019468531 @default.
- W1512758510 cites W2020098163 @default.
- W1512758510 cites W2020933453 @default.
- W1512758510 cites W2022191797 @default.
- W1512758510 cites W2024312973 @default.
- W1512758510 cites W2027168471 @default.
- W1512758510 cites W2029243855 @default.
- W1512758510 cites W2029870728 @default.
- W1512758510 cites W2030625746 @default.
- W1512758510 cites W2031371282 @default.
- W1512758510 cites W2031786428 @default.
- W1512758510 cites W2032033086 @default.
- W1512758510 cites W2032627402 @default.
- W1512758510 cites W2032947833 @default.
- W1512758510 cites W2033515555 @default.
- W1512758510 cites W2033663596 @default.
- W1512758510 cites W2035992736 @default.
- W1512758510 cites W2040889233 @default.
- W1512758510 cites W2042425801 @default.
- W1512758510 cites W2049702932 @default.
- W1512758510 cites W2050809104 @default.
- W1512758510 cites W2051149259 @default.
- W1512758510 cites W2054328989 @default.
- W1512758510 cites W2056402278 @default.
- W1512758510 cites W2058401104 @default.
- W1512758510 cites W2062694778 @default.
- W1512758510 cites W2063948863 @default.
- W1512758510 cites W2070271329 @default.
- W1512758510 cites W2071314483 @default.
- W1512758510 cites W2072340467 @default.
- W1512758510 cites W2077385831 @default.
- W1512758510 cites W2079709458 @default.
- W1512758510 cites W2080010624 @default.
- W1512758510 cites W2080484067 @default.
- W1512758510 cites W2082668382 @default.
- W1512758510 cites W2083416188 @default.
- W1512758510 cites W2084753433 @default.
- W1512758510 cites W2087402016 @default.
- W1512758510 cites W2087634635 @default.
- W1512758510 cites W2088022780 @default.
- W1512758510 cites W2089866099 @default.
- W1512758510 cites W2091735648 @default.
- W1512758510 cites W2092581818 @default.
- W1512758510 cites W2093141196 @default.
- W1512758510 cites W2098989693 @default.
- W1512758510 cites W2099980231 @default.
- W1512758510 cites W2100915582 @default.
- W1512758510 cites W2108529527 @default.
- W1512758510 cites W2109014940 @default.
- W1512758510 cites W2113145530 @default.
- W1512758510 cites W2113544353 @default.
- W1512758510 cites W2113842221 @default.
- W1512758510 cites W2113873655 @default.
- W1512758510 cites W2116587224 @default.