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- W1512778862 endingPage "406" @default.
- W1512778862 startingPage "394" @default.
- W1512778862 abstract "If validated, diet‐derived foreign microRNA absorption and function in consuming vertebrates would drastically alter our understanding of nutrition and ecology. RNA interference (RNAi) mechanisms of Caenorhabditis elegans are enhanced by uptake of environmental RNA and amplification and systemic distribution of RNAi effectors. Therapeutic exploitation of RNAi in treating human disease is difficult because these accessory processes are absent or diminished in most animals. A recent report challenged multiple paradigms, suggesting that ingested microRNAs (miRNAs) are transferred to blood, accumulate in tissues, and exert canonical regulation of endogenous transcripts. Independent replication of these findings has been elusive, and multiple disconfirmatory findings have been published. In the face of mounting negative results, any additional positive reports must provide the proverbial “extraordinary proof” to support such claims. In this article, we review the evidence for and against a significant role for dietary miRNAs in influencing gene expression, and make recommendations for future studies. Also watch the Video Abstract" @default.
- W1512778862 created "2016-06-24" @default.
- W1512778862 creator A5010914519 @default.
- W1512778862 creator A5078835957 @default.
- W1512778862 date "2014-01-16" @default.
- W1512778862 modified "2023-10-16" @default.
- W1512778862 title "Transfer and functional consequences of dietary microRNAs in vertebrates: Concepts in search of corroboration" @default.
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