FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1512782010> ?p ?o ?g. }

• W1512782010 endingPage "803" @default.
• W1512782010 startingPage "798" @default.
• W1512782010 abstract "We showed previously that parathyroid hormone (PTH) may stimulate the endothelial expression of pro-atherosclerotic and pro-inflammatory markers. Considering the impact of PTH on vasculature, we decided to evaluate its effect on mRNA and intra-cellular protein expressions of endothelial vascular endothelial growth factor (VEGF) taking into account that VEGF may play a role in the pathogenesis of endothelial dysfunctions.Human umbilical vein cords endothelial cells (HUVEC) were stimulated for 24 h with 10(-12)-10(-10) mol L(-1) PTH. The VEGF-165 mRNA expression (critical in stimulating endothelial cell proliferation) was evaluated by RT/PCR and the intra-cellular VEGF protein expression by flow cytometry. The pathways by which PTH may have an effect on VEGF expression were also evaluated.PTH (10(-10) mol L(-1)) significantly increased VEGF-165 mRNA expression (P < 0.05). The addition of 50 nmol L(-1) protein kinase C (PKC) and 10 micromol L(-1) protein kinase A (PKA) inhibitors significantly reduced the VEGF-165 mRNA expression (P = 0.01). We also examined whether nitric oxide (NO) may be involved in the PTH-induced stimulation of VEGF-165 expression. Pre-treatment of the cells with 200 micromol L-nitro arginine methyl ester (L-NAME, NO synthase inhibitor) was found to inhibit VEGF-165 mRNA expression (P = 0.006). VEGF protein could not be detected in the medium of HUVEC but it was present in the cell cytoplasm. PTH had no significant effect on cytoplasmatic VEGF protein expression.The stimulatory effect of PTH on endothelial VEGF-165 mRNA expression is partly through PKC and PKA pathways and is also NO dependent." @default.
• W1512782010 created "2016-06-24" @default.
• W1512782010 creator A5003703821 @default.
• W1512782010 creator A5008084635 @default.
• W1512782010 creator A5070111089 @default.
• W1512782010 creator A5086429939 @default.
• W1512782010 date "2008-10-21" @default.
• W1512782010 modified "2023-10-17" @default.
• W1512782010 title "Parathyroid hormone stimulates the endothelial expression of vascular endothelial growth factor" @default.
• W1512782010 cites W1561059299 @default.
• W1512782010 cites W1933628558 @default.
• W1512782010 cites W1980214938 @default.
• W1512782010 cites W1985712533 @default.
• W1512782010 cites W1987713859 @default.
• W1512782010 cites W1988688040 @default.
• W1512782010 cites W1996005927 @default.
• W1512782010 cites W1997254182 @default.
• W1512782010 cites W2000292756 @default.
• W1512782010 cites W2012926932 @default.
• W1512782010 cites W2013038209 @default.
• W1512782010 cites W2015199717 @default.
• W1512782010 cites W2023861169 @default.
• W1512782010 cites W2032175307 @default.
• W1512782010 cites W2042719333 @default.
• W1512782010 cites W2061810671 @default.
• W1512782010 cites W2076219981 @default.
• W1512782010 cites W2082157250 @default.
• W1512782010 cites W2084818589 @default.
• W1512782010 cites W2086883857 @default.
• W1512782010 cites W2121594719 @default.
• W1512782010 cites W2133353133 @default.
• W1512782010 cites W2136973364 @default.
• W1512782010 cites W2137893922 @default.
• W1512782010 cites W2153726078 @default.
• W1512782010 cites W2163127813 @default.
• W1512782010 cites W2171715330 @default.
• W1512782010 cites W36186310 @default.
• W1512782010 doi "https://doi.org/10.1111/j.1365-2362.2008.02033.x" @default.
• W1512782010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19021696" @default.
• W1512782010 hasPublicationYear "2008" @default.
• W1512782010 type Work @default.
• W1512782010 sameAs 1512782010 @default.
• W1512782010 citedByCount "46" @default.
• W1512782010 countsByYear W15127820102012 @default.
• W1512782010 countsByYear W15127820102013 @default.
• W1512782010 countsByYear W15127820102014 @default.
• W1512782010 countsByYear W15127820102015 @default.
• W1512782010 countsByYear W15127820102016 @default.
• W1512782010 countsByYear W15127820102017 @default.
• W1512782010 countsByYear W15127820102018 @default.
• W1512782010 countsByYear W15127820102019 @default.
• W1512782010 countsByYear W15127820102020 @default.
• W1512782010 countsByYear W15127820102021 @default.
• W1512782010 countsByYear W15127820102022 @default.
• W1512782010 countsByYear W15127820102023 @default.
• W1512782010 crossrefType "journal-article" @default.
• W1512782010 hasAuthorship W1512782010A5003703821 @default.
• W1512782010 hasAuthorship W1512782010A5008084635 @default.
• W1512782010 hasAuthorship W1512782010A5070111089 @default.
• W1512782010 hasAuthorship W1512782010A5086429939 @default.
• W1512782010 hasConcept C104317684 @default.
• W1512782010 hasConcept C105580179 @default.
• W1512782010 hasConcept C123012128 @default.
• W1512782010 hasConcept C126322002 @default.
• W1512782010 hasConcept C134018914 @default.
• W1512782010 hasConcept C146285616 @default.
• W1512782010 hasConcept C167734588 @default.
• W1512782010 hasConcept C184235292 @default.
• W1512782010 hasConcept C185592680 @default.
• W1512782010 hasConcept C195794163 @default.
• W1512782010 hasConcept C202751555 @default.
• W1512782010 hasConcept C2776992346 @default.
• W1512782010 hasConcept C2777025900 @default.
• W1512782010 hasConcept C2777411675 @default.
• W1512782010 hasConcept C2781208988 @default.
• W1512782010 hasConcept C519063684 @default.
• W1512782010 hasConcept C55493867 @default.
• W1512782010 hasConcept C62478195 @default.
• W1512782010 hasConcept C71924100 @default.
• W1512782010 hasConcept C86803240 @default.
• W1512782010 hasConcept C95444343 @default.
• W1512782010 hasConcept C97029542 @default.
• W1512782010 hasConceptScore W1512782010C104317684 @default.
• W1512782010 hasConceptScore W1512782010C105580179 @default.
• W1512782010 hasConceptScore W1512782010C123012128 @default.
• W1512782010 hasConceptScore W1512782010C126322002 @default.
• W1512782010 hasConceptScore W1512782010C134018914 @default.
• W1512782010 hasConceptScore W1512782010C146285616 @default.
• W1512782010 hasConceptScore W1512782010C167734588 @default.
• W1512782010 hasConceptScore W1512782010C184235292 @default.
• W1512782010 hasConceptScore W1512782010C185592680 @default.
• W1512782010 hasConceptScore W1512782010C195794163 @default.
• W1512782010 hasConceptScore W1512782010C202751555 @default.
• W1512782010 hasConceptScore W1512782010C2776992346 @default.
• W1512782010 hasConceptScore W1512782010C2777025900 @default.
• W1512782010 hasConceptScore W1512782010C2777411675 @default.
• W1512782010 hasConceptScore W1512782010C2781208988 @default.
• W1512782010 hasConceptScore W1512782010C519063684 @default.

• next