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- W1512794080 abstract "应用表达TSHR-A亚单位的重组腺病毒免疫BALB/c小鼠建立甲亢模型.分别用1010和108病毒颗粒/50μl PBS的腺病毒免疫6～8周雌性BALB/c小鼠,在完成3次免疫后通过检测血清T4、TRAb水平,甲状腺体积及甲状腺病理来鉴定动物模型.在所有接受免疫的小鼠中.甲亢的发生率为75%,表现为血清T4、TRAb增高,甲状腺体积增大,甲状腺病理表现符合甲亢.低免疫剂量组和高免疫剂量组小鼠血清T4较对照组均显著增高,两组间无显著性差异;低免疫剂量组和高免疫剂量组小鼠血清TRAb水平均显著高于对照组,前者血清TRAb水平低于后者.该模型具有成模率高,稳定性好的特点.低免疫剂量建立的动物模型更符合GD特点." @default.
- W1512794080 created "2016-06-24" @default.
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- W1512794080 date "2008-08-31" @default.
- W1512794080 modified "2023-09-23" @default.
- W1512794080 title "表达TSHR-A亚单位的腺病毒免疫BALB/c雌性小鼠建立甲亢模型" @default.
- W1512794080 hasPublicationYear "2008" @default.
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