Matches in SemOpenAlex for { <https://semopenalex.org/work/W1512797323> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1512797323 endingPage "1828" @default.
- W1512797323 startingPage "1822" @default.
- W1512797323 abstract "Certain allele-specific alloreactive T cell clones do not recognize the products expressed by some B cell lines that, according to typing methods other than sequencing, carry the allelic molecules recognized by these clones. In order to characterize the naturally occurring sequence polymorphisms putatively responsible for the differential allorecognition of these class II molecules, we have determined the third and/or second exon nucleotide sequences of HLA-DRB1, -DRB3/4/5, -DQB1, and -DQA1 genes from 35 representative lymphoblastoid cell lines. In some cases, the lack of recognition correlates with the presence of single amino acid substitutions in either the second or third hypervariable region (HVR) of the first domain of these molecules. In other cases, the differentially allorecognized class II molecules have identical second and/or first domain amino acid sequences. These findings indicate that a) class II MHC-alloreactive T cell clones can distinguish between molecules with identical amino acid sequences expressed by B cell lines established from unrelated individuals; b) allorecognition of class II molecules is sensitive to naturally occurring single amino acid substitutions in either the second HVR of class II molecules, which is unavailable to interact with TCR residues, or the third HVR. Our results also suggest that 1) in different B cell lines, identical class II molecules may present different endogenous peptides, which may behave as histocompatibility Ag; 2) the peptide-binding specificity of a class II molecule may be affected by amino acid substitutions in its second HVR (Ag-binding site); and 3) human class II allorecognition may be restricted by epitopes contributed by residues of their third HVR." @default.
- W1512797323 created "2016-06-24" @default.
- W1512797323 creator A5024832913 @default.
- W1512797323 creator A5036565288 @default.
- W1512797323 creator A5049423827 @default.
- W1512797323 creator A5054307423 @default.
- W1512797323 creator A5087132678 @default.
- W1512797323 creator A5088027632 @default.
- W1512797323 date "1991-03-15" @default.
- W1512797323 modified "2023-09-23" @default.
- W1512797323 title "Alloreactive T cells can distinguish between the same human class II MHC products on different B cell lines." @default.
- W1512797323 doi "https://doi.org/10.4049/jimmunol.146.6.1822" @default.
- W1512797323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1706381" @default.
- W1512797323 hasPublicationYear "1991" @default.
- W1512797323 type Work @default.
- W1512797323 sameAs 1512797323 @default.
- W1512797323 citedByCount "11" @default.
- W1512797323 crossrefType "journal-article" @default.
- W1512797323 hasAuthorship W1512797323A5024832913 @default.
- W1512797323 hasAuthorship W1512797323A5036565288 @default.
- W1512797323 hasAuthorship W1512797323A5049423827 @default.
- W1512797323 hasAuthorship W1512797323A5054307423 @default.
- W1512797323 hasAuthorship W1512797323A5087132678 @default.
- W1512797323 hasAuthorship W1512797323A5088027632 @default.
- W1512797323 hasBestOaLocation W15127973231 @default.
- W1512797323 hasConcept C104317684 @default.
- W1512797323 hasConcept C153911025 @default.
- W1512797323 hasConcept C167625842 @default.
- W1512797323 hasConcept C170627219 @default.
- W1512797323 hasConcept C200315206 @default.
- W1512797323 hasConcept C207936829 @default.
- W1512797323 hasConcept C2778814158 @default.
- W1512797323 hasConcept C515207424 @default.
- W1512797323 hasConcept C54355233 @default.
- W1512797323 hasConcept C81566733 @default.
- W1512797323 hasConcept C86803240 @default.
- W1512797323 hasConceptScore W1512797323C104317684 @default.
- W1512797323 hasConceptScore W1512797323C153911025 @default.
- W1512797323 hasConceptScore W1512797323C167625842 @default.
- W1512797323 hasConceptScore W1512797323C170627219 @default.
- W1512797323 hasConceptScore W1512797323C200315206 @default.
- W1512797323 hasConceptScore W1512797323C207936829 @default.
- W1512797323 hasConceptScore W1512797323C2778814158 @default.
- W1512797323 hasConceptScore W1512797323C515207424 @default.
- W1512797323 hasConceptScore W1512797323C54355233 @default.
- W1512797323 hasConceptScore W1512797323C81566733 @default.
- W1512797323 hasConceptScore W1512797323C86803240 @default.
- W1512797323 hasIssue "6" @default.
- W1512797323 hasLocation W15127973231 @default.
- W1512797323 hasLocation W15127973232 @default.
- W1512797323 hasOpenAccess W1512797323 @default.
- W1512797323 hasPrimaryLocation W15127973231 @default.
- W1512797323 hasRelatedWork W1512797323 @default.
- W1512797323 hasRelatedWork W1553470951 @default.
- W1512797323 hasRelatedWork W1650711999 @default.
- W1512797323 hasRelatedWork W1992730395 @default.
- W1512797323 hasRelatedWork W2001548392 @default.
- W1512797323 hasRelatedWork W2030437891 @default.
- W1512797323 hasRelatedWork W2045757315 @default.
- W1512797323 hasRelatedWork W2062982445 @default.
- W1512797323 hasRelatedWork W2406662957 @default.
- W1512797323 hasRelatedWork W968747768 @default.
- W1512797323 hasVolume "146" @default.
- W1512797323 isParatext "false" @default.
- W1512797323 isRetracted "false" @default.
- W1512797323 magId "1512797323" @default.
- W1512797323 workType "article" @default.