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- W1512841339 abstract "Heterogeneous tumors may have a wide spectrum of radiation sensitivities due to factors like their clonal distribution and degree of genetic instability and gradients of oxygen and nutrients. Recent studies demonstrate that the radiation response of heterogeneous tumors can be well described by a single effective clonogen compartment when the dose–response relation is of main interest. When a correct description of the clonogenic survival is important at both low and high doses, a description based on one sensitive and one resistant clonogen compartment will generally be necessary and sufficient. Such a description is valuable, for example, when in vivo positron emission tomography-CT data are acquired early in the treatment to predict the required curative radiation dose. Methods are given for derivation of the sensitive and resistant cell compartments based on clinically observed dose–response relations and degrees of hypoxia. Principal characteristics of heterogeneous tumors are derived, such as the dose D t describing the transition zone between sensitive and resistant cell predomination, where the maximum change in slope of the cell survival curve occurs. Since the effective compartments are based on the whole spectrum of radiation resistance, they will take both extreme and intermediate values into account, thus providing an accurate description of radiation response over the entire range of clinically relevant doses." @default.
- W1512841339 created "2016-06-24" @default.
- W1512841339 creator A5003138660 @default.
- W1512841339 date "2014-01-01" @default.
- W1512841339 modified "2023-09-30" @default.
- W1512841339 title "Accurate Description of Heterogeneous Tumors by Their Effective Radiation-Sensitive and -Resistant Cell Compartments" @default.
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- W1512841339 doi "https://doi.org/10.1016/b978-0-444-53632-7.00904-7" @default.
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