Matches in SemOpenAlex for { <https://semopenalex.org/work/W1512868117> ?p ?o ?g. }
- W1512868117 endingPage "694" @default.
- W1512868117 startingPage "677" @default.
- W1512868117 abstract "Deleted in Liver Cancer-1 (DLC1) is a RhoGTPase-activating protein (GAP) and a tumor suppressor often downregulated in cancers. It is localized to the focal adhesions (FAs) and its absence leads to enhanced cell migration, invasion, and metastasis. Although DLC1 interacts with focal adhesion kinase (FAK), talin, and tensin, its role in focal adhesions dynamics remains unclear. We examined the effect of DLC1 in Human Foreskin Fibroblasts and determined its localization, dynamics and impact on paxillin by Fluorescence Recovery After Photobleaching at both nascent and mature focal adhesions. During early cell spreading, DLC1 is preferentially localized at the inner/mature adhesions whereas phosphorylated paxillin occupies the outer/nascent FAs. In addition, DLC1 downregulates paxillin turnover in a process, that does not require its GAP activity. Instead, it requires the presence of FAK. Acting in concert, both DLC1 and FAK could provide a unique spatio-temporal mechanism to regulate paxillin function in tissue homeostasis. © 2014 Wiley Periodicals, Inc." @default.
- W1512868117 created "2016-06-24" @default.
- W1512868117 creator A5016144610 @default.
- W1512868117 creator A5027796004 @default.
- W1512868117 creator A5055998574 @default.
- W1512868117 creator A5077999999 @default.
- W1512868117 date "2014-12-01" @default.
- W1512868117 modified "2023-09-27" @default.
- W1512868117 title "Concerted modulation of paxillin dynamics at focal adhesions by deleted in liver cancer-1 and focal adhesion kinase during early cell spreading" @default.
- W1512868117 cites W1597994956 @default.
- W1512868117 cites W1967265143 @default.
- W1512868117 cites W1969342647 @default.
- W1512868117 cites W1977489066 @default.
- W1512868117 cites W1979346765 @default.
- W1512868117 cites W1983443986 @default.
- W1512868117 cites W1985000689 @default.
- W1512868117 cites W2004275852 @default.
- W1512868117 cites W2012726972 @default.
- W1512868117 cites W2028042707 @default.
- W1512868117 cites W2028691987 @default.
- W1512868117 cites W2044895919 @default.
- W1512868117 cites W2048209624 @default.
- W1512868117 cites W2048278564 @default.
- W1512868117 cites W2060160757 @default.
- W1512868117 cites W2060630299 @default.
- W1512868117 cites W2062682840 @default.
- W1512868117 cites W2066637671 @default.
- W1512868117 cites W2067363611 @default.
- W1512868117 cites W2080146774 @default.
- W1512868117 cites W2098343919 @default.
- W1512868117 cites W2102732577 @default.
- W1512868117 cites W2104794759 @default.
- W1512868117 cites W2108733739 @default.
- W1512868117 cites W2108770100 @default.
- W1512868117 cites W2109328746 @default.
- W1512868117 cites W2117040422 @default.
- W1512868117 cites W2119920331 @default.
- W1512868117 cites W2122038069 @default.
- W1512868117 cites W2130189983 @default.
- W1512868117 cites W2130838656 @default.
- W1512868117 cites W2135925002 @default.
- W1512868117 cites W2142962833 @default.
- W1512868117 cites W2144423098 @default.
- W1512868117 cites W2145613550 @default.
- W1512868117 cites W2149352954 @default.
- W1512868117 cites W2152348521 @default.
- W1512868117 cites W2157216811 @default.
- W1512868117 cites W2157313296 @default.
- W1512868117 cites W2158769524 @default.
- W1512868117 cites W2162752530 @default.
- W1512868117 cites W2164017897 @default.
- W1512868117 cites W2168717243 @default.
- W1512868117 cites W2170034857 @default.
- W1512868117 cites W2171179595 @default.
- W1512868117 cites W2171229821 @default.
- W1512868117 cites W2189033227 @default.
- W1512868117 cites W3081487045 @default.
- W1512868117 cites W4247056331 @default.
- W1512868117 doi "https://doi.org/10.1002/cm.21201" @default.
- W1512868117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25448629" @default.
- W1512868117 hasPublicationYear "2014" @default.
- W1512868117 type Work @default.
- W1512868117 sameAs 1512868117 @default.
- W1512868117 citedByCount "18" @default.
- W1512868117 countsByYear W15128681172015 @default.
- W1512868117 countsByYear W15128681172016 @default.
- W1512868117 countsByYear W15128681172017 @default.
- W1512868117 countsByYear W15128681172018 @default.
- W1512868117 countsByYear W15128681172019 @default.
- W1512868117 countsByYear W15128681172020 @default.
- W1512868117 countsByYear W15128681172021 @default.
- W1512868117 countsByYear W15128681172022 @default.
- W1512868117 countsByYear W15128681172023 @default.
- W1512868117 crossrefType "journal-article" @default.
- W1512868117 hasAuthorship W1512868117A5016144610 @default.
- W1512868117 hasAuthorship W1512868117A5027796004 @default.
- W1512868117 hasAuthorship W1512868117A5055998574 @default.
- W1512868117 hasAuthorship W1512868117A5077999999 @default.
- W1512868117 hasConcept C108391706 @default.
- W1512868117 hasConcept C116581196 @default.
- W1512868117 hasConcept C11960822 @default.
- W1512868117 hasConcept C137738243 @default.
- W1512868117 hasConcept C1491633281 @default.
- W1512868117 hasConcept C151166631 @default.
- W1512868117 hasConcept C184235292 @default.
- W1512868117 hasConcept C2777609662 @default.
- W1512868117 hasConcept C2779549131 @default.
- W1512868117 hasConcept C55493867 @default.
- W1512868117 hasConcept C62478195 @default.
- W1512868117 hasConcept C86554907 @default.
- W1512868117 hasConcept C86803240 @default.
- W1512868117 hasConcept C90934575 @default.
- W1512868117 hasConcept C95444343 @default.
- W1512868117 hasConcept C97029542 @default.
- W1512868117 hasConceptScore W1512868117C108391706 @default.
- W1512868117 hasConceptScore W1512868117C116581196 @default.
- W1512868117 hasConceptScore W1512868117C11960822 @default.
- W1512868117 hasConceptScore W1512868117C137738243 @default.