FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1513029763> ?p ?o ?g. }

• W1513029763 endingPage "25" @default.
• W1513029763 startingPage "1" @default.
• W1513029763 abstract "During the development of the neocortex, cell proliferation occurs in two specialized zones adjacent to the lateral ventricle. One of these zones, the ventricular zone, produces most of the neurons of the neocortex. The proliferating population that resides in the ventricular zone is a pseudostratified ventricular epithelium (PVE) that looks uniform in routine histological preparations, but is, in fact, an active and dynamically changing population. In the mouse, over the course of a 6-day period, the PVE produces approximately 95% of the neurons of the adult neocortex. During this time, the cell cycle of the PVE population lengthens from about 8 h to over 18 h and the progenitor population passes through a total of 11 cell cycles. This 6-day, 11-cell cycle period comprises the “neuronogenetic interval” (NI). At each passage through the cell cycle, the proportion of daughter cells that exit the cell cycle (Q cells) increases from 0 at the onset of the NI to 1 at the end of the NI. The proportion of daughter cells that re-enter the cell cycle (P cells) changes in a complementary fashion from 1 at the onset of the NI to 0 at the end of the NI. This set of systematic changes in the cell cycle and the output from the proliferative population of the PVE allows a quantitative and mathematical treatment of the expansion of the PVE and the growth of the cortical plate that nicely accounts for the observed expansion and growth of the developing neocortex. In addition, we show that the cells produced during a 2-h window of development during specific cell cycles reside in a specific set of laminae in the adult cortex, but that the distributions of the output from consecutive cell cycles overlap. These dynamic events occur in all areas of the PVE underlying the neocortex, but there is a gradient of maturation that begins in the rostrolateral neocortex near the striatotelencephalic junction and which spreads across the surface of the neocortex over a period of 24–36 h. The presence of the gradient across the hemisphere is a possible source of positional information that could be exploited during development to establish the areal borders that characterize the adult neocortex." @default.
• W1513029763 created "2016-06-24" @default.
• W1513029763 creator A5024886799 @default.
• W1513029763 creator A5026657616 @default.
• W1513029763 creator A5031649553 @default.
• W1513029763 creator A5064701139 @default.
• W1513029763 date "2002-01-01" @default.
• W1513029763 modified "2023-10-18" @default.
• W1513029763 title "Population Dynamics During Cell Proliferation and Neuronogenesis in the Developing Murine Neocortex" @default.
• W1513029763 cites W1500073381 @default.
• W1513029763 cites W1506357334 @default.
• W1513029763 cites W1559406855 @default.
• W1513029763 cites W1579609657 @default.
• W1513029763 cites W1582081614 @default.
• W1513029763 cites W1790244735 @default.
• W1513029763 cites W1878988573 @default.
• W1513029763 cites W1919729993 @default.
• W1513029763 cites W1970473817 @default.
• W1513029763 cites W1972303276 @default.
• W1513029763 cites W1976078978 @default.
• W1513029763 cites W1979952856 @default.
• W1513029763 cites W1981164058 @default.
• W1513029763 cites W1986926812 @default.
• W1513029763 cites W1994406909 @default.
• W1513029763 cites W1995194777 @default.
• W1513029763 cites W1997406173 @default.
• W1513029763 cites W1999450284 @default.
• W1513029763 cites W2001769052 @default.
• W1513029763 cites W2013148439 @default.
• W1513029763 cites W2013466759 @default.
• W1513029763 cites W2016827719 @default.
• W1513029763 cites W2016997675 @default.
• W1513029763 cites W2019009046 @default.
• W1513029763 cites W2021515035 @default.
• W1513029763 cites W2026904817 @default.
• W1513029763 cites W2031468048 @default.
• W1513029763 cites W2038458357 @default.
• W1513029763 cites W2052530372 @default.
• W1513029763 cites W2060101684 @default.
• W1513029763 cites W2063565088 @default.
• W1513029763 cites W2066511633 @default.
• W1513029763 cites W2070671082 @default.
• W1513029763 cites W2071435286 @default.
• W1513029763 cites W2072673889 @default.
• W1513029763 cites W2086630567 @default.
• W1513029763 cites W2087965564 @default.
• W1513029763 cites W2090143287 @default.
• W1513029763 cites W2091630929 @default.
• W1513029763 cites W2093712120 @default.
• W1513029763 cites W2094073595 @default.
• W1513029763 cites W2106306931 @default.
• W1513029763 cites W2106841325 @default.
• W1513029763 cites W2119624274 @default.
• W1513029763 cites W2124134886 @default.
• W1513029763 cites W2147471332 @default.
• W1513029763 cites W2200900155 @default.
• W1513029763 cites W2612570922 @default.
• W1513029763 doi "https://doi.org/10.1007/978-3-540-46006-0_1" @default.
• W1513029763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12353465" @default.
• W1513029763 hasPublicationYear "2002" @default.
• W1513029763 type Work @default.
• W1513029763 sameAs 1513029763 @default.
• W1513029763 citedByCount "61" @default.
• W1513029763 countsByYear W15130297632012 @default.
• W1513029763 countsByYear W15130297632013 @default.
• W1513029763 countsByYear W15130297632014 @default.
• W1513029763 countsByYear W15130297632016 @default.
• W1513029763 countsByYear W15130297632017 @default.
• W1513029763 countsByYear W15130297632018 @default.
• W1513029763 countsByYear W15130297632019 @default.
• W1513029763 countsByYear W15130297632020 @default.
• W1513029763 countsByYear W15130297632021 @default.
• W1513029763 crossrefType "book-chapter" @default.
• W1513029763 hasAuthorship W1513029763A5024886799 @default.
• W1513029763 hasAuthorship W1513029763A5026657616 @default.
• W1513029763 hasAuthorship W1513029763A5031649553 @default.
• W1513029763 hasAuthorship W1513029763A5064701139 @default.
• W1513029763 hasConcept C121332964 @default.
• W1513029763 hasConcept C1491633281 @default.
• W1513029763 hasConcept C169760540 @default.
• W1513029763 hasConcept C201750760 @default.
• W1513029763 hasConcept C24890656 @default.
• W1513029763 hasConcept C2777222312 @default.
• W1513029763 hasConcept C2781291010 @default.
• W1513029763 hasConcept C28328180 @default.
• W1513029763 hasConcept C2908647359 @default.
• W1513029763 hasConcept C29537977 @default.
• W1513029763 hasConcept C54355233 @default.
• W1513029763 hasConcept C62112901 @default.
• W1513029763 hasConcept C71924100 @default.
• W1513029763 hasConcept C85813293 @default.
• W1513029763 hasConcept C86803240 @default.
• W1513029763 hasConcept C95444343 @default.
• W1513029763 hasConcept C99454951 @default.
• W1513029763 hasConceptScore W1513029763C121332964 @default.
• W1513029763 hasConceptScore W1513029763C1491633281 @default.
• W1513029763 hasConceptScore W1513029763C169760540 @default.
• W1513029763 hasConceptScore W1513029763C201750760 @default.

• next