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• W1513175965 abstract "The interaction with membranes of three anti-cancer drugs of the ellipticine family was studied by fluorescence quenching of membrane probes. The fluorescence of three probes, located at different levels in membranes, was quenched by addition of two types of ellipticine derivatives, one amphiphilic drug (9-methoxyellipticine) and two dipolar molecules (9-aminoellipticine and 9-hydroxyellipticine). By comparing the quenching curves obtained, the following can be proposed. a) 9-Methoxyellipticine can penetrate deeper in the lipid layers than 9-aminoellipticine and 9-hydroxyellipticine can. b) The three drugs are able to penetrate at least between the first methylene groups of the acyl chains of lipids in liposomes. c) In an isolated bacterial membrane, only 9-methoxyellipticine can be located in the region of the first methylene groups of lipids, the two dipolar drugs being adsorbed on the membrane surface. It was also shown that cholesterol hindered the penetration of 9-methoxyellipticine in the bilayer of liposomes." @default.
• W1513175965 created "2016-06-24" @default.
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• W1513175965 date "1983-06-01" @default.
• W1513175965 modified "2023-10-16" @default.
• W1513175965 title "Localization of Ellipticine Derivatives Interacting with Membranes. A Fluorescence-Quenching Study" @default.
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• W1513175965 doi "https://doi.org/10.1111/j.1432-1033.1983.tb07469.x" @default.
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