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- W1513201398 abstract "Hirschsprung's disease (HD) is characterized by an absence of ganglion cells in the nerve plexuses of the distal large bowel. The lack of ganglion cells produces a functional obstruction and leads to dilatation of the bowel that is proximal to the aganglionic zone. The commonly quoted incidence of HD is 1:5000. The classic description of HD was first presented in detail by a Danish pediatrician, Harald Hirschsprung in 1886. The absence of ganglion cells in the distal large bowel was first reported by Tittel, but the crucial role of this finding as the primary pathology was not appreciated until the late 1940s. In 1948 the first successful operation for HD was performed by Swenson and Bill. This was a rectosigmoidectomy and later became known as the Swenson operation." @default.
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- W1513201398 date "2006-11-09" @default.
- W1513201398 modified "2023-10-07" @default.
- W1513201398 title "Hirschsprung's disease" @default.
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- W1513201398 doi "https://doi.org/10.1017/cbo9780511545757.031" @default.
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