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- W1513202016 abstract "L-carnitine is suggested as a potential therapeutic agent in metabolic encephalopathies, such as ammonia-precipitated hepatic encephalopathy (HE). In humans, ammonia is produced mainly by the metabolism of proteins and amino acids. Most of the ammonia is detoxified by the urea cycle which is located in the liver. Thus, disturbances of the urea cycle in the liver lead to higher ammonia levels in blood. In humans, hyperammonemia (HA) arises mainly from liver diseases and is in most cases associated with HE. There are currently only a few therapeutic strategies, and outcome expectations for patients with HE are poor. Lcarnitine and its acyl-derivates are suggested as potential and low-cost therapeutic agents. In animal models, L-carnitine has been shown to counteract neurotoxic effects of ammonia, increase energy metabolism and decrease mortality. A protective effect against ammoniaprecipitated HE has also been observed in cirrhotic patients. A review of the literature offers in vitro and in vivo studies, as well as human trials with promising results. This chapter provides a comprehensive summary and a summarized discussion of the literature data concerning the effects of L-carnitine, with special emphasis on hyperammonemic syndromes and HE." @default.
- W1513202016 created "2016-06-24" @default.
- W1513202016 creator A5018389713 @default.
- W1513202016 creator A5020137450 @default.
- W1513202016 date "2012-04-25" @default.
- W1513202016 modified "2023-09-27" @default.
- W1513202016 title "L-carnitine in Hyperammonemia and Hepatic Encephalopathy" @default.
- W1513202016 cites W102148687 @default.
- W1513202016 cites W128171387 @default.
- W1513202016 cites W128436451 @default.
- W1513202016 cites W1500541392 @default.
- W1513202016 cites W1509861130 @default.
- W1513202016 cites W1519004085 @default.
- W1513202016 cites W1546298995 @default.
- W1513202016 cites W1549403331 @default.
- W1513202016 cites W1599462883 @default.
- W1513202016 cites W1608390320 @default.
- W1513202016 cites W1820460245 @default.
- W1513202016 cites W1903340256 @default.
- W1513202016 cites W1963588191 @default.
- W1513202016 cites W1966343871 @default.
- W1513202016 cites W1967842522 @default.
- W1513202016 cites W1968952783 @default.
- W1513202016 cites W1973576309 @default.
- W1513202016 cites W1977222362 @default.
- W1513202016 cites W1977709442 @default.
- W1513202016 cites W1982049192 @default.
- W1513202016 cites W1982693929 @default.
- W1513202016 cites W1984013660 @default.
- W1513202016 cites W1984089779 @default.
- W1513202016 cites W1984256619 @default.
- W1513202016 cites W1984801719 @default.
- W1513202016 cites W1984927454 @default.
- W1513202016 cites W1985006564 @default.
- W1513202016 cites W1986202044 @default.
- W1513202016 cites W1986626457 @default.
- W1513202016 cites W1989692754 @default.
- W1513202016 cites W1990110631 @default.
- W1513202016 cites W1997295596 @default.
- W1513202016 cites W2001061566 @default.
- W1513202016 cites W2003491261 @default.
- W1513202016 cites W2003947524 @default.
- W1513202016 cites W2010288117 @default.
- W1513202016 cites W2010847506 @default.
- W1513202016 cites W2011051704 @default.
- W1513202016 cites W2011149655 @default.
- W1513202016 cites W2011473644 @default.
- W1513202016 cites W2018118901 @default.
- W1513202016 cites W2018305539 @default.
- W1513202016 cites W2019008972 @default.
- W1513202016 cites W2031988484 @default.
- W1513202016 cites W2036180883 @default.
- W1513202016 cites W2036544714 @default.
- W1513202016 cites W2039560063 @default.
- W1513202016 cites W2042823827 @default.
- W1513202016 cites W2045886000 @default.
- W1513202016 cites W2046799445 @default.
- W1513202016 cites W2048420531 @default.
- W1513202016 cites W2050689042 @default.
- W1513202016 cites W2051207479 @default.
- W1513202016 cites W2051998570 @default.
- W1513202016 cites W2058276705 @default.
- W1513202016 cites W2060494021 @default.
- W1513202016 cites W2060650343 @default.
- W1513202016 cites W2061656366 @default.
- W1513202016 cites W2063559846 @default.
- W1513202016 cites W2065370260 @default.
- W1513202016 cites W2065502274 @default.
- W1513202016 cites W2067762538 @default.
- W1513202016 cites W2069588147 @default.
- W1513202016 cites W2069754795 @default.
- W1513202016 cites W2070292087 @default.
- W1513202016 cites W2071838680 @default.
- W1513202016 cites W2073218335 @default.
- W1513202016 cites W2078048047 @default.
- W1513202016 cites W2079995698 @default.
- W1513202016 cites W2081076262 @default.
- W1513202016 cites W2082809972 @default.
- W1513202016 cites W2086914035 @default.
- W1513202016 cites W2087148853 @default.
- W1513202016 cites W2091610947 @default.
- W1513202016 cites W2102083512 @default.
- W1513202016 cites W2102440831 @default.
- W1513202016 cites W2104051447 @default.
- W1513202016 cites W2104760225 @default.
- W1513202016 cites W2106876204 @default.
- W1513202016 cites W2109115714 @default.
- W1513202016 cites W2114316261 @default.
- W1513202016 cites W2115417400 @default.
- W1513202016 cites W2126068729 @default.
- W1513202016 cites W2134866080 @default.
- W1513202016 cites W2160453061 @default.
- W1513202016 cites W2166871827 @default.
- W1513202016 cites W22138893 @default.
- W1513202016 cites W2288320014 @default.
- W1513202016 cites W2405318846 @default.
- W1513202016 cites W2419603248 @default.
- W1513202016 cites W254833807 @default.
- W1513202016 cites W3145577325 @default.
- W1513202016 cites W3190914252 @default.