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- W1513266825 abstract "A novel high affinity dopaminergic ligand, N ‐( p ‐aminophenethyl)spiroperidol, has been synthesized and radioiodinated to a specific radioactivity of 2175 . Binding of this ligand to bovine anterior pituitary membranes is: (i) rapid (40–60 min to equilibrium at 25°C) and reversible t = 1 h at 25°C); (ii) saturable and of high affinity ( K D ~ 20 pM) and (iii) displays a typical D 2 ‐dopaminergic specificity. The ligand, which identifies the same number of receptor sites as other tritiated antagonist ligands, can be used in different tissues and preparations to delineate the characteristics of the D 2 receptor. Thus, this high affinity, high specific radioactivity ligand ( N ‐( p ‐amino‐ m ‐[ 125 I]iodophenethyl)spiroperidol) represents a tool which until now had not been available for the characterization of the D 2 ‐dopamine receptor." @default.
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- W1513266825 date "1984-10-29" @default.
- W1513266825 modified "2023-09-25" @default.
- W1513266825 title "A novel radioiodinated high affinity ligand for the D2 -dopamine receptor" @default.
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- W1513266825 doi "https://doi.org/10.1016/0014-5793(84)81213-2" @default.
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