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- W1513302908 abstract "本文由文献报道的己知小分子苗头化合物片段出发，基于其与β-分泌酶结合的晶体结构，通过结构修饰设计了全新的非肽类小分子β-分泌酶抑制剂：六氢嘧啶-5-醇系列及其两类类似物系列。计算机辅助药物设计的研究得到了良好的结果。我们测试了各类母核的β-分泌酶抑制活性，结果进一步支持了我们的设计思路。" @default.
- W1513302908 created "2016-06-24" @default.
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- W1513302908 date "2010-01-01" @default.
- W1513302908 modified "2023-09-23" @default.
- W1513302908 title "六氢嘧啶-5-醇类新型非肽类β-分泌酶抑制剂的基于结构的药物分子设计" @default.
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