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- W1513303790 endingPage "1035" @default.
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- W1513303790 abstract "Autophagy is an ancient mechanism of protein degradation and a novel antimicrobial strategy. With respect to host defences against mycobacteria, autophagy plays a crucial role in antimycobacterial resistance, and contributes to immune surveillance of intracellular pathogens and vaccine efficacy. Vitamin D3 contributes to host immune responses against Mycobacterium tuberculosis through LL-37/hCAP-18, which is the only cathelicidin identified to date in humans. In this review, we discuss recent advances in our understanding of host immune strategies against mycobacteria, including vitamin D-mediated innate immunity and autophagy activation. This review also addresses our current understanding regarding the autophagy connection to principal innate machinery, such as ubiquitin- or inflammasome-involved pathways. Integrated dialog between autophagy and innate immunity may contribute to adequate host immune defences against mycobacterial infection." @default.
- W1513303790 created "2016-06-24" @default.
- W1513303790 creator A5088283936 @default.
- W1513303790 date "2010-06-14" @default.
- W1513303790 modified "2023-10-03" @default.
- W1513303790 title "Innate immunity to mycobacteria: vitamin D and autophagy" @default.
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- W1513303790 doi "https://doi.org/10.1111/j.1462-5822.2010.01491.x" @default.
- W1513303790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20557314" @default.
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