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• W1513444791 endingPage "811" @default.
• W1513444791 startingPage "798" @default.
• W1513444791 abstract "To test the hypothesis of an involvement of tachykinins in destabilization and hyperexcitation of neuronal circuits, gliosis, and neuroinflammation during cerebral ischemia, we investigated cell-specific expressional changes of the genes encoding substance P (SP), neurokinin B (NKB), and the tachykinin/neurokinin receptors (NK1, NK2, and NK3) after middle cerebral artery occlusion (MCAO) in the rat. Our analysis by quantitative <i>in situ</i> hybridization, immunohistochemistry, and confocal microscopy was concentrated on cerebrocortical areas that survive primary infarction but undergo secondary damage. Here, SP-encoding preprotachykinin-A and NK1 mRNA levels and SP-like immunoreactivity were transiently increased in GABAergic interneurons at 2 d after MCAO. Coincidently, MCAO caused a marked expression of SP and NK1 in a subpopulation of glutamatergic pyramidal cells, and in some neurons SP and NK1 mRNAs were coinduced. Elevated levels of the NKB-encoding preprotachykinin-B mRNA and of NKB-like immunoreactivity at 2 and 7 d after MCAO were confined to GABAergic interneurons. In parallel, the expression of NK3 was markedly downregulated in pyramidal neurons. MCAO caused transient NK1 expression in activated cerebrovenular endothelium within and adjacent to the infarct. NK1 expression was absent from activated astroglia or microglia. The differential ischemia-induced plasticity of the tachykinin system in distinct inhibitory and excitatory cerebrocortical circuits suggests that it may be involved in the balance of endogenous neuroprotection and neurotoxicity by enhancing GABAergic inhibitory circuits or by facilitating glutamate-mediated hyperexcitability. The transient induction of NK1 in cerebrovenular endothelium may contribute to ischemia-induced edema and leukocyte diapedesis. Brain tachykinin receptors are proposed as potential drug targets in stroke." @default.
• W1513444791 created "2016-06-24" @default.
• W1513444791 creator A5014152401 @default.
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• W1513444791 creator A5053579288 @default.
• W1513444791 creator A5080129940 @default.
• W1513444791 creator A5083679881 @default.
• W1513444791 date "2001-02-01" @default.
• W1513444791 modified "2023-10-03" @default.
• W1513444791 title "Adaptive Plasticity in Tachykinin and Tachykinin Receptor Expression after Focal Cerebral Ischemia Is Differentially Linked to GABAergic and Glutamatergic Cerebrocortical Circuits and Cerebrovenular Endothelium" @default.
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• W1513444791 doi "https://doi.org/10.1523/jneurosci.21-03-00798.2001" @default.
• W1513444791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762313" @default.
• W1513444791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11157066" @default.
• W1513444791 hasPublicationYear "2001" @default.
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