Matches in SemOpenAlex for { <https://semopenalex.org/work/W1513477879> ?p ?o ?g. }
- W1513477879 endingPage "823" @default.
- W1513477879 startingPage "818" @default.
- W1513477879 abstract "AIM: We examined cytokine levels in steroid-refractory ulcerative colitis (UC) patients before and after administration of tacrolimus. METHODS: A total of 124 patients with UC were enrolled, and 13 with steroid-refractory UC were evaluated. Patients were given a 0.025 mg/kg oral dose of tacrolimus twice daily with plasma trough levels of 10 to 15 ng/mL for the first 2 weeks, and doses were maintained to achieve plasma levels between 5 and 10 ng/mL. The Disease Activity Index (DAI) and serum CRP levels were determined before and 12 weeks after treatment. Serum levels of 17 cytokines were simultaneously determined using a Bio-Plex suspension array system before and 12 weeks after treatment. RESULTS: DAI scores and DAI mucosal appearance subscores after treatment were significantly decreased compared to before treatment (P<0.05). CRP levels were significantly decreased after treatment. G-CSF levels were significantly decreased after treatment compared to before treatment in all patients. In the efficacy group, IL-8 and G-CSF levels were significantly decreased after treatment compared to before treatment, and a significant correlation was noted between CRP and IL-8 levels. CONCLUSION: Treatment with tacrolimus reduced serum IL-8 and G-CSF levels in UC patients, which may be associated with an overall reduction in disease severity." @default.
- W1513477879 created "2016-06-24" @default.
- W1513477879 creator A5002059217 @default.
- W1513477879 creator A5042700054 @default.
- W1513477879 creator A5086128035 @default.
- W1513477879 date "2013-10-21" @default.
- W1513477879 modified "2023-09-26" @default.
- W1513477879 title "Serial Changes of Cytokines in Steroid-Refractory Ulcerative Colitis Patients Treated with Tacrolimus" @default.
- W1513477879 cites W133234478 @default.
- W1513477879 cites W162223277 @default.
- W1513477879 cites W1964526307 @default.
- W1513477879 cites W1971262349 @default.
- W1513477879 cites W1986097686 @default.
- W1513477879 cites W1987602796 @default.
- W1513477879 cites W1987925515 @default.
- W1513477879 cites W1994099910 @default.
- W1513477879 cites W2001987698 @default.
- W1513477879 cites W2006654054 @default.
- W1513477879 cites W2007665550 @default.
- W1513477879 cites W2008908364 @default.
- W1513477879 cites W2017443683 @default.
- W1513477879 cites W2018301699 @default.
- W1513477879 cites W2027886654 @default.
- W1513477879 cites W2048251542 @default.
- W1513477879 cites W2049561355 @default.
- W1513477879 cites W2053050463 @default.
- W1513477879 cites W2058100963 @default.
- W1513477879 cites W2065158037 @default.
- W1513477879 cites W20761558 @default.
- W1513477879 cites W2086189875 @default.
- W1513477879 cites W2087090420 @default.
- W1513477879 cites W2102804688 @default.
- W1513477879 cites W2104097403 @default.
- W1513477879 cites W2115509137 @default.
- W1513477879 cites W2121650731 @default.
- W1513477879 cites W2128986200 @default.
- W1513477879 cites W2130004075 @default.
- W1513477879 cites W2133648960 @default.
- W1513477879 cites W2135398656 @default.
- W1513477879 cites W2136628679 @default.
- W1513477879 cites W2137200390 @default.
- W1513477879 cites W2149526023 @default.
- W1513477879 cites W2163713576 @default.
- W1513477879 cites W2253732259 @default.
- W1513477879 cites W2321205867 @default.
- W1513477879 cites W234681446 @default.
- W1513477879 cites W2418659712 @default.
- W1513477879 cites W3029052526 @default.
- W1513477879 cites W2073907850 @default.
- W1513477879 hasPublicationYear "2013" @default.
- W1513477879 type Work @default.
- W1513477879 sameAs 1513477879 @default.
- W1513477879 citedByCount "1" @default.
- W1513477879 countsByYear W15134778792015 @default.
- W1513477879 crossrefType "journal-article" @default.
- W1513477879 hasAuthorship W1513477879A5002059217 @default.
- W1513477879 hasAuthorship W1513477879A5042700054 @default.
- W1513477879 hasAuthorship W1513477879A5086128035 @default.
- W1513477879 hasConcept C121332964 @default.
- W1513477879 hasConcept C126322002 @default.
- W1513477879 hasConcept C142424586 @default.
- W1513477879 hasConcept C2778690821 @default.
- W1513477879 hasConcept C2779134260 @default.
- W1513477879 hasConcept C2780479503 @default.
- W1513477879 hasConcept C2909675724 @default.
- W1513477879 hasConcept C2911091166 @default.
- W1513477879 hasConcept C71924100 @default.
- W1513477879 hasConcept C87355193 @default.
- W1513477879 hasConcept C90924648 @default.
- W1513477879 hasConceptScore W1513477879C121332964 @default.
- W1513477879 hasConceptScore W1513477879C126322002 @default.
- W1513477879 hasConceptScore W1513477879C142424586 @default.
- W1513477879 hasConceptScore W1513477879C2778690821 @default.
- W1513477879 hasConceptScore W1513477879C2779134260 @default.
- W1513477879 hasConceptScore W1513477879C2780479503 @default.
- W1513477879 hasConceptScore W1513477879C2909675724 @default.
- W1513477879 hasConceptScore W1513477879C2911091166 @default.
- W1513477879 hasConceptScore W1513477879C71924100 @default.
- W1513477879 hasConceptScore W1513477879C87355193 @default.
- W1513477879 hasConceptScore W1513477879C90924648 @default.
- W1513477879 hasIssue "10" @default.
- W1513477879 hasLocation W15134778791 @default.
- W1513477879 hasOpenAccess W1513477879 @default.
- W1513477879 hasPrimaryLocation W15134778791 @default.
- W1513477879 hasRelatedWork W2052139596 @default.
- W1513477879 hasRelatedWork W2148199912 @default.
- W1513477879 hasRelatedWork W2347466107 @default.
- W1513477879 hasRelatedWork W2360326789 @default.
- W1513477879 hasRelatedWork W2361475498 @default.
- W1513477879 hasRelatedWork W2369622423 @default.
- W1513477879 hasRelatedWork W2370542119 @default.
- W1513477879 hasRelatedWork W2379234595 @default.
- W1513477879 hasRelatedWork W2382965758 @default.
- W1513477879 hasRelatedWork W2391139306 @default.
- W1513477879 hasRelatedWork W2461761530 @default.
- W1513477879 hasRelatedWork W3029128617 @default.
- W1513477879 hasRelatedWork W3029562848 @default.
- W1513477879 hasRelatedWork W3029722941 @default.