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- W1513518027 abstract "Aim: We aimed to demonstrate the relationship between pregnancy associated plasma protein-A (PAPP-A) levels below 3th percentile ( ≤0.30 Multiples of Median (MoM)) with second trimester placental size, mean Uterine Artery (UtA) doppler Pulsatility Index (PI) and adverse obstetric outcomes. Material and Methods: We recruited 32 women with PAPP-A levels ≤ 0.30 corrected MoM (Group 1), and 50 women with PAPP-A levels > 0.30 corrected MoM (Group 2), attended to Dr. Lutfi Kirdar Kartal Education and Research Hospital perinatology outpatient clinic, between September 2010 and January 2011. Pregnant women were reevaluated at 18-24 weeks with placental size measurement and mean UtA doppler indices. Mean UtA doppler PI ≥1.45 considered to be abnormal as increased UtA resistance. We also grouped women as low PAPP-A and increased mean UtA PI (Group 1: n =7) and normal PAPP-A and normal mean UtA PI ( Group 2: n = 75 ). All women are asked in postnatal period for pregnancy complications like preeclampsia (PE), intrauterine growth retardation (IUGR), preterm delivery, oligohydramniosis and stillbirth. Results: When women were grouped according to the PAPP-A level adverse pregnancy outcomes were more prevalent in low PAPP-A group but statistically significant difference was seen only in preeclampsia (p=0.02). Second trimester placental size and UtA PI levels were not significantly different between groups. When grouped according to the PAPP-A and UtA PI levels, IUGR and oligohydramniosis was significantly higher (p= 0.03 and p=0.04 respectively) and birth weight was significantly lower (p=0.02) in low PAPP-A and high UtA PI group. There was no satistically significant difference in PE among groups (p=0.23). Conclusion: Our results have shown that it is possible to predict unfavorable effects of placental insufficiency on mother and fetus, but it is obvious that there is no single screening method. Randomised clinical trials with larger sample sizes using combination of biochemical and ultrasonographic parameters is necessary for prediction of adverse pregnancy outcomes." @default.
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- W1513518027 date "2014-10-01" @default.
- W1513518027 modified "2023-10-18" @default.
- W1513518027 title "Birinci Trimester Gebelikle İlişkili Plasma Protein-A Düzeyinin, İkinci Trimester Uterin Arter Doppler, Plasental Boyut ve Kötü Obstetrik Sonuçlarla İlişkisi" @default.
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