Matches in SemOpenAlex for { <https://semopenalex.org/work/W151358801> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W151358801 abstract "Gut microbiota-mediated effects on the immune system can influence cytokine production in gut-associated lymphoid tissues (GALT). The extent to which gender-associated differences in gut microbiota composition influence mucosal cytokine patterns is as yet undetermined, as is the impact such differences may have on the ability of fermentable material to modulate immune activity through effects on the gut microbiota. To explore these questions, we analyzed the effects of a fructo-oligosaccharide (FOS)-supplemented Purina chow diet on mucosal cytokine profiles, focusing on IL-6 (pro-inflammatory), IL-4 (TH 2 ) and IL-10 (regulatory T reg ). To compare gender-associated effects of FOS at the gut microbial and intestinal epithelial level, we measured fecal short chain fatty acid profiles (by gas chromatography) and mucin gene MUC2 expression (determined by quantitative real-time PCR). No major FOS-induced changes in cytokine profiles (vs. control) were observed in the ileum of male or female rats, although gender-specific differences in cytokine levels were observed. Cecal IL-6 (7732.49 ± 863 pg/g) was higher in FOS-fed male rats compared to FOS-fed female rats (5057.9 ± 536.5 pg/g). Cecal IL-10 was significantly lower in male rats fed the control diet (5301.2 ± 241.6 pg/g) relative to female rats fed the same diet (8164 ± 843.6 pg/g). However, cecal IL-10 was elevated in FOS-fed male rats (6484.3 ± 1269.7 pg/g) to levels similar to those of FOS-fed female rats (6662.4 ± 335.6 pg/g), indicating a potential differential effect of dietary FOS on this regulatory cytokine in males and females. Fecal butyric acid concentrations in FOS-fed male rats (35.1 ± 7.1 mmol/g) were significantly higher than those in FOS-fed female rats (13.6 ± 2.6 mmol/g), suggesting a gender-associated difference in the effects of FOS at the gut microbial level. Preliminary results indicate higher cecal MUC2 expression in male rats relative to female rats. These findings illustrate that fermentation-associated luminal changes may affect GALT immune activity in a gender-specific fashion." @default.
- W151358801 created "2016-06-24" @default.
- W151358801 creator A5025828085 @default.
- W151358801 creator A5043812842 @default.
- W151358801 creator A5053224750 @default.
- W151358801 creator A5071748393 @default.
- W151358801 creator A5078610258 @default.
- W151358801 date "2013-09-01" @default.
- W151358801 modified "2023-10-02" @default.
- W151358801 title "235" @default.
- W151358801 doi "https://doi.org/10.1016/j.cyto.2013.06.238" @default.
- W151358801 hasPublicationYear "2013" @default.
- W151358801 type Work @default.
- W151358801 sameAs 151358801 @default.
- W151358801 citedByCount "0" @default.
- W151358801 crossrefType "journal-article" @default.
- W151358801 hasAuthorship W151358801A5025828085 @default.
- W151358801 hasAuthorship W151358801A5043812842 @default.
- W151358801 hasAuthorship W151358801A5053224750 @default.
- W151358801 hasAuthorship W151358801A5071748393 @default.
- W151358801 hasAuthorship W151358801A5078610258 @default.
- W151358801 hasConcept C100544194 @default.
- W151358801 hasConcept C104317684 @default.
- W151358801 hasConcept C126322002 @default.
- W151358801 hasConcept C134018914 @default.
- W151358801 hasConcept C150194340 @default.
- W151358801 hasConcept C179264091 @default.
- W151358801 hasConcept C203014093 @default.
- W151358801 hasConcept C2776229602 @default.
- W151358801 hasConcept C2776979534 @default.
- W151358801 hasConcept C2777116383 @default.
- W151358801 hasConcept C2777226302 @default.
- W151358801 hasConcept C2778690821 @default.
- W151358801 hasConcept C539455810 @default.
- W151358801 hasConcept C55493867 @default.
- W151358801 hasConcept C61716771 @default.
- W151358801 hasConcept C71924100 @default.
- W151358801 hasConcept C86803240 @default.
- W151358801 hasConcept C8891405 @default.
- W151358801 hasConcept C89423630 @default.
- W151358801 hasConceptScore W151358801C100544194 @default.
- W151358801 hasConceptScore W151358801C104317684 @default.
- W151358801 hasConceptScore W151358801C126322002 @default.
- W151358801 hasConceptScore W151358801C134018914 @default.
- W151358801 hasConceptScore W151358801C150194340 @default.
- W151358801 hasConceptScore W151358801C179264091 @default.
- W151358801 hasConceptScore W151358801C203014093 @default.
- W151358801 hasConceptScore W151358801C2776229602 @default.
- W151358801 hasConceptScore W151358801C2776979534 @default.
- W151358801 hasConceptScore W151358801C2777116383 @default.
- W151358801 hasConceptScore W151358801C2777226302 @default.
- W151358801 hasConceptScore W151358801C2778690821 @default.
- W151358801 hasConceptScore W151358801C539455810 @default.
- W151358801 hasConceptScore W151358801C55493867 @default.
- W151358801 hasConceptScore W151358801C61716771 @default.
- W151358801 hasConceptScore W151358801C71924100 @default.
- W151358801 hasConceptScore W151358801C86803240 @default.
- W151358801 hasConceptScore W151358801C8891405 @default.
- W151358801 hasConceptScore W151358801C89423630 @default.
- W151358801 hasLocation W1513588011 @default.
- W151358801 hasOpenAccess W151358801 @default.
- W151358801 hasPrimaryLocation W1513588011 @default.
- W151358801 hasRelatedWork W2058852640 @default.
- W151358801 hasRelatedWork W2119511745 @default.
- W151358801 hasRelatedWork W2152268651 @default.
- W151358801 hasRelatedWork W2188324775 @default.
- W151358801 hasRelatedWork W2469894986 @default.
- W151358801 hasRelatedWork W2606748729 @default.
- W151358801 hasRelatedWork W2778291081 @default.
- W151358801 hasRelatedWork W2800783226 @default.
- W151358801 hasRelatedWork W2884364625 @default.
- W151358801 hasRelatedWork W2889926944 @default.
- W151358801 hasRelatedWork W2910708789 @default.
- W151358801 hasRelatedWork W2921640196 @default.
- W151358801 hasRelatedWork W2947892482 @default.
- W151358801 hasRelatedWork W2948810272 @default.
- W151358801 hasRelatedWork W3005537322 @default.
- W151358801 hasRelatedWork W3015031155 @default.
- W151358801 hasRelatedWork W3045528154 @default.
- W151358801 hasRelatedWork W3109352126 @default.
- W151358801 hasRelatedWork W3158149495 @default.
- W151358801 hasRelatedWork W2401492430 @default.
- W151358801 isParatext "false" @default.
- W151358801 isRetracted "false" @default.
- W151358801 magId "151358801" @default.
- W151358801 workType "article" @default.