Matches in SemOpenAlex for { <https://semopenalex.org/work/W1513625905> ?p ?o ?g. }
- W1513625905 endingPage "426" @default.
- W1513625905 startingPage "397" @default.
- W1513625905 abstract "Down syndrome (DS) results from the presence of an extra copy of genes on the long-arm of chromosome 21. Aberrant expression of these trisomic genes leads to widespread neurological changes that vary in their severity. However, how the presence of extra genes affects the physiological and behavioral phenotypes associated with DS is not well understood. The most likely cause of the complex DS phenotypes is the overexpression of dosage-sensitive genes. However, other factors, such as the complex interactions between gene products as proteins and noncoding RNAs, certainly play significant roles contributing to the spectrum of severity. Here we will review evidence regarding how the overexpression of one particular gene encoding for G-protein-activated inward rectifying potassium type 2 (GIRK2) channel subunit and its coupling to GABAB receptors may contribute to a range of mental and functional disabilities in DS." @default.
- W1513625905 created "2016-06-24" @default.
- W1513625905 creator A5016377862 @default.
- W1513625905 creator A5046515686 @default.
- W1513625905 creator A5049889130 @default.
- W1513625905 creator A5067370467 @default.
- W1513625905 creator A5078012500 @default.
- W1513625905 date "2010-01-01" @default.
- W1513625905 modified "2023-09-27" @default.
- W1513625905 title "GABAB–GIRK2-Mediated Signaling in Down Syndrome" @default.
- W1513625905 cites W111593348 @default.
- W1513625905 cites W1493864045 @default.
- W1513625905 cites W1512145210 @default.
- W1513625905 cites W1553532993 @default.
- W1513625905 cites W1561294879 @default.
- W1513625905 cites W156908873 @default.
- W1513625905 cites W1569781386 @default.
- W1513625905 cites W1586474684 @default.
- W1513625905 cites W1665093015 @default.
- W1513625905 cites W1845046061 @default.
- W1513625905 cites W1935009340 @default.
- W1513625905 cites W1964683842 @default.
- W1513625905 cites W1967628781 @default.
- W1513625905 cites W1968536098 @default.
- W1513625905 cites W1970476580 @default.
- W1513625905 cites W1974428682 @default.
- W1513625905 cites W1980083167 @default.
- W1513625905 cites W1980171323 @default.
- W1513625905 cites W1980364661 @default.
- W1513625905 cites W1980825603 @default.
- W1513625905 cites W1982330698 @default.
- W1513625905 cites W1983154949 @default.
- W1513625905 cites W1987580641 @default.
- W1513625905 cites W1989308975 @default.
- W1513625905 cites W1992836821 @default.
- W1513625905 cites W1992933562 @default.
- W1513625905 cites W1995952358 @default.
- W1513625905 cites W1996375567 @default.
- W1513625905 cites W1996754856 @default.
- W1513625905 cites W2002708545 @default.
- W1513625905 cites W2002734542 @default.
- W1513625905 cites W2003049938 @default.
- W1513625905 cites W2003714676 @default.
- W1513625905 cites W2004554306 @default.
- W1513625905 cites W2004599241 @default.
- W1513625905 cites W2004790690 @default.
- W1513625905 cites W2006124071 @default.
- W1513625905 cites W2009816239 @default.
- W1513625905 cites W2013386989 @default.
- W1513625905 cites W2014271878 @default.
- W1513625905 cites W2019373887 @default.
- W1513625905 cites W2021540664 @default.
- W1513625905 cites W2022936592 @default.
- W1513625905 cites W2032912767 @default.
- W1513625905 cites W2042916026 @default.
- W1513625905 cites W2044715689 @default.
- W1513625905 cites W2044851415 @default.
- W1513625905 cites W2045264711 @default.
- W1513625905 cites W2047960464 @default.
- W1513625905 cites W2049511526 @default.
- W1513625905 cites W2049747642 @default.
- W1513625905 cites W2050452127 @default.
- W1513625905 cites W2051951639 @default.
- W1513625905 cites W2054351623 @default.
- W1513625905 cites W2058257681 @default.
- W1513625905 cites W2058369296 @default.
- W1513625905 cites W2059409177 @default.
- W1513625905 cites W2062346208 @default.
- W1513625905 cites W2063366770 @default.
- W1513625905 cites W2063432323 @default.
- W1513625905 cites W2063904398 @default.
- W1513625905 cites W2064093540 @default.
- W1513625905 cites W2064358122 @default.
- W1513625905 cites W2064568891 @default.
- W1513625905 cites W2066015662 @default.
- W1513625905 cites W2067308061 @default.
- W1513625905 cites W2067598670 @default.
- W1513625905 cites W2069282289 @default.
- W1513625905 cites W2071633033 @default.
- W1513625905 cites W2073248118 @default.
- W1513625905 cites W2073700418 @default.
- W1513625905 cites W2075834102 @default.
- W1513625905 cites W2077273976 @default.
- W1513625905 cites W2079155607 @default.
- W1513625905 cites W2079973367 @default.
- W1513625905 cites W2080082038 @default.
- W1513625905 cites W2081389808 @default.
- W1513625905 cites W2082869264 @default.
- W1513625905 cites W2082980172 @default.
- W1513625905 cites W2083883439 @default.
- W1513625905 cites W2084233122 @default.
- W1513625905 cites W2085702771 @default.
- W1513625905 cites W2086452840 @default.
- W1513625905 cites W2088291608 @default.
- W1513625905 cites W2088693700 @default.
- W1513625905 cites W2089405384 @default.
- W1513625905 cites W2094183590 @default.
- W1513625905 cites W2094489923 @default.