FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1513681002> ?p ?o ?g. }

• W1513681002 endingPage "409" @default.
• W1513681002 startingPage "403" @default.
• W1513681002 abstract "Psoriatic plaques contain an increased number of mast cells. Both the histamine concentration and release are increased in lesional skin but the underlying mechanisms are unclear. One hypothesis is that neuropeptides transmitted from thin sensory cutaneous nerves continuously stimulate mast cell release of histamine. The aim of this study was to test this hypothesis by examining if topical anaesthesia of these nerves inhibits histamine release in psoriatic skin. The concentration of histamine was measured in microdialysates obtained from lesional and non-lesional skin before and during topical anaesthesia. Concomitantly skin blood flow was measured with scanning laser Doppler (perfusion) and/or 133Xe clearance (flow) techniques in the microdialysis area. The histamine concentrations (mean +/- SEM) were 34 +/- 4 (n = 21), 14 +/- 1.5 (n = 18) (P < 0. 001) and 2.8 +/- 1 nmol/L (n = 10) in lesional and non-lesional skin and plasma, respectively. After anaesthesia of the microdialysis areas the histamine concentration in psoriatic skin increased to 44 +/- 4 nmol/L (n = 19, P < 0.05), but remained unaltered in uninvolved skin. In anaesthetized lesional skin the perfusion decreased from 3.7 +/- 0.2 to 2.5 +/- 0.3 V and blood flow decreased from 14 +/- 5 to 9 +/- 1 mL/min per 100 g (P < 0.001, n = 10). The calculated release of dermal histamine in involved skin (198 +/- 30 pmol/min per 100 g, n = 10) remained unchanged after local anaesthesia. The results indicate that neurogenic activation of mast cells is of minor importance for continuous histamine release in psoriatic skin and that the vasodilatation in the psoriatic plaque is not mediated by histamine." @default.
• W1513681002 created "2016-06-24" @default.
• W1513681002 creator A5014126308 @default.
• W1513681002 creator A5022316371 @default.
• W1513681002 creator A5048761449 @default.
• W1513681002 creator A5076550646 @default.
• W1513681002 date "1998-09-01" @default.
• W1513681002 modified "2023-10-16" @default.
• W1513681002 title "Nerve-induced histamine release is of little importance in psoriatic skin" @default.
• W1513681002 cites W1963572696 @default.
• W1513681002 cites W1966666533 @default.
• W1513681002 cites W1967234965 @default.
• W1513681002 cites W1968048884 @default.
• W1513681002 cites W1971268898 @default.
• W1513681002 cites W1976246982 @default.
• W1513681002 cites W1982774183 @default.
• W1513681002 cites W1985176577 @default.
• W1513681002 cites W1987357649 @default.
• W1513681002 cites W1989677663 @default.
• W1513681002 cites W1999994095 @default.
• W1513681002 cites W2001660474 @default.
• W1513681002 cites W2002137290 @default.
• W1513681002 cites W2004372679 @default.
• W1513681002 cites W2012675036 @default.
• W1513681002 cites W2021158476 @default.
• W1513681002 cites W2045341219 @default.
• W1513681002 cites W2047346625 @default.
• W1513681002 cites W2053703609 @default.
• W1513681002 cites W2057038278 @default.
• W1513681002 cites W2058709979 @default.
• W1513681002 cites W2063000685 @default.
• W1513681002 cites W2075583795 @default.
• W1513681002 cites W2076350174 @default.
• W1513681002 cites W2077744324 @default.
• W1513681002 cites W2084163614 @default.
• W1513681002 cites W2084516683 @default.
• W1513681002 cites W2084678325 @default.
• W1513681002 cites W2087434807 @default.
• W1513681002 cites W2090919416 @default.
• W1513681002 cites W2095144160 @default.
• W1513681002 cites W2099661425 @default.
• W1513681002 cites W2107682764 @default.
• W1513681002 cites W2109824025 @default.
• W1513681002 cites W2121704168 @default.
• W1513681002 cites W2157302643 @default.
• W1513681002 cites W2159760007 @default.
• W1513681002 cites W2171263166 @default.
• W1513681002 cites W4236569219 @default.
• W1513681002 cites W4239542141 @default.
• W1513681002 cites W4254554467 @default.
• W1513681002 cites W4256123925 @default.
• W1513681002 doi "https://doi.org/10.1046/j.1365-2133.1998.02402.x" @default.
• W1513681002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9767283" @default.
• W1513681002 hasPublicationYear "1998" @default.
• W1513681002 type Work @default.
• W1513681002 sameAs 1513681002 @default.
• W1513681002 citedByCount "13" @default.
• W1513681002 countsByYear W15136810022012 @default.
• W1513681002 countsByYear W15136810022013 @default.
• W1513681002 countsByYear W15136810022014 @default.
• W1513681002 countsByYear W15136810022020 @default.
• W1513681002 crossrefType "journal-article" @default.
• W1513681002 hasAuthorship W1513681002A5014126308 @default.
• W1513681002 hasAuthorship W1513681002A5022316371 @default.
• W1513681002 hasAuthorship W1513681002A5048761449 @default.
• W1513681002 hasAuthorship W1513681002A5076550646 @default.
• W1513681002 hasConcept C1122143 @default.
• W1513681002 hasConcept C126322002 @default.
• W1513681002 hasConcept C134018914 @default.
• W1513681002 hasConcept C146957229 @default.
• W1513681002 hasConcept C170493617 @default.
• W1513681002 hasConcept C185592680 @default.
• W1513681002 hasConcept C203014093 @default.
• W1513681002 hasConcept C2776885963 @default.
• W1513681002 hasConcept C2777459323 @default.
• W1513681002 hasConcept C2778997900 @default.
• W1513681002 hasConcept C2779726688 @default.
• W1513681002 hasConcept C2780564577 @default.
• W1513681002 hasConcept C42219234 @default.
• W1513681002 hasConcept C50156730 @default.
• W1513681002 hasConcept C529278444 @default.
• W1513681002 hasConcept C54355233 @default.
• W1513681002 hasConcept C63180777 @default.
• W1513681002 hasConcept C71924100 @default.
• W1513681002 hasConcept C86803240 @default.
• W1513681002 hasConceptScore W1513681002C1122143 @default.
• W1513681002 hasConceptScore W1513681002C126322002 @default.
• W1513681002 hasConceptScore W1513681002C134018914 @default.
• W1513681002 hasConceptScore W1513681002C146957229 @default.
• W1513681002 hasConceptScore W1513681002C170493617 @default.
• W1513681002 hasConceptScore W1513681002C185592680 @default.
• W1513681002 hasConceptScore W1513681002C203014093 @default.
• W1513681002 hasConceptScore W1513681002C2776885963 @default.
• W1513681002 hasConceptScore W1513681002C2777459323 @default.
• W1513681002 hasConceptScore W1513681002C2778997900 @default.
• W1513681002 hasConceptScore W1513681002C2779726688 @default.
• W1513681002 hasConceptScore W1513681002C2780564577 @default.
• W1513681002 hasConceptScore W1513681002C42219234 @default.

• next