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- W1513681981 abstract "In the current project, situated at the interface of chemistry and virology, complementary drug discovery approaches (high-throughput screening and structurebaseddrug design) have been exploited in order to discover novel small molecule inhibitors of hRSV.Thus, a novel fluorescence-based high-throughput screening assay was developed using known anti-virals for validation: EC50 of Ribavirin ca. 30 μM, and EC50 of JNJ- 4749914 ca. 0.4 nM. This assay was then used to screen a natural product-like library.The crystal structure of a small molecule in complex with the fusion protein of hRSV was used in a virtual high-throughput screening campaign. A range of virtual libraries(libraries of likely synthetically accessible and commercially available molecule) were screened virtually using eHiTS against this binding cavity. This led to the identification of a potential novel series of hRSV fusion inhibitors, whose syntheses and biological evaluation have been described.Novel confocal imaging experiments were also carried out on a known hRSV fusion inhibitor (JNJ-4749914) in order to gain more insight in the compound's mode of actionby visualising virus entry inhibition in epithelial cells." @default.
- W1513681981 created "2016-06-24" @default.
- W1513681981 creator A5042345785 @default.
- W1513681981 date "2012-11-01" @default.
- W1513681981 modified "2023-09-23" @default.
- W1513681981 title "Complementary approaches to target human respiratory syncytial virus using small molecule ligands" @default.
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