FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1513693864> ?p ?o ?g. }

• W1513693864 endingPage "764" @default.
• W1513693864 startingPage "755" @default.
• W1513693864 abstract "Abstract Hypertrophic scar ( HS c) contraction following burn injury causes contractures. Contractures are painful and disfiguring. Current therapies are marginally effective. To study pathogenesis and develop new therapies, a murine model is needed. We have created a validated immune‐competent murine HS c model. A third‐degree burn was created on dorsum of C 57 BL /6 mice. Three days postburn, tissue was excised and grafted with ear skin. Graft contraction was analyzed and tissue harvested on different time points. Outcomes were compared with human condition to validate the model. To confirm graft survival, green fluorescent protein ( GFP ) mice were used, and histologic analysis was performed to differentiate between ear and back skin. Role of panniculus carnosus in contraction was analyzed. Cellularity was assessed with 4′,6‐diamidino‐2‐phenylindole. Collagen maturation was assessed with Picro‐sirius red. Mast cells were stained with T oluidine blue. Macrophages were detected with F 4/80 immune. Vascularity was assessed with CD 31 immune. RNA for contractile proteins was detected by quantitative real‐time polymerase chain reaction (q RT ‐ PCR ). Elastic moduli of skin and scar tissue were analyzed using a microstrain analyzer. Grafts contracted to ∼45% of their original size by day 14 and maintained their size. Grafting of GFP mouse skin onto wild‐type mice, and analysis of dermal thickness and hair follicle density, confirmed graft survival. Interestingly, hair follicles disappeared after grafting and regenerated in ear skin configuration by day 30. Radiological analysis revealed that panniculus carnosus doesn't contribute to contraction. Microscopic analyses showed that grafts show increase in cellularity. Granulation tissue formed after day 3. Collagen analysis revealed increases in collagen maturation over time. CD 31 stain revealed increased vascularity. Macrophages and mast cells were increased. q RT ‐ PCR showed up‐regulation of transforming growth factor beta, alpha smooth muscle actin, and rho‐associated protein kinase 2 in HS c. Tensile testing revealed that human skin and scar tissues are tougher than mouse skin and scar tissues." @default.
• W1513693864 created "2016-06-24" @default.
• W1513693864 creator A5008685812 @default.
• W1513693864 creator A5010311645 @default.
• W1513693864 creator A5011291680 @default.
• W1513693864 creator A5026452682 @default.
• W1513693864 creator A5027795357 @default.
• W1513693864 creator A5027852438 @default.
• W1513693864 creator A5028402841 @default.
• W1513693864 creator A5028626094 @default.
• W1513693864 creator A5035544818 @default.
• W1513693864 creator A5038629120 @default.
• W1513693864 creator A5050822671 @default.
• W1513693864 creator A5059973732 @default.
• W1513693864 creator A5066964238 @default.
• W1513693864 date "2014-11-01" @default.
• W1513693864 modified "2023-10-11" @default.
• W1513693864 title "A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies" @default.
• W1513693864 cites W1484369928 @default.
• W1513693864 cites W1523516129 @default.
• W1513693864 cites W170411476 @default.
• W1513693864 cites W1963484569 @default.
• W1513693864 cites W1971661406 @default.
• W1513693864 cites W1974185118 @default.
• W1513693864 cites W1976117064 @default.
• W1513693864 cites W1976141939 @default.
• W1513693864 cites W1976572971 @default.
• W1513693864 cites W1979880331 @default.
• W1513693864 cites W1981269419 @default.
• W1513693864 cites W1986015537 @default.
• W1513693864 cites W1996131014 @default.
• W1513693864 cites W1999301598 @default.
• W1513693864 cites W2012560240 @default.
• W1513693864 cites W2014231503 @default.
• W1513693864 cites W2014758968 @default.
• W1513693864 cites W2016193552 @default.
• W1513693864 cites W2019568084 @default.
• W1513693864 cites W2020149007 @default.
• W1513693864 cites W2025742313 @default.
• W1513693864 cites W2030029307 @default.
• W1513693864 cites W2031261551 @default.
• W1513693864 cites W2032013289 @default.
• W1513693864 cites W2039295429 @default.
• W1513693864 cites W2047151166 @default.
• W1513693864 cites W2051247089 @default.
• W1513693864 cites W2051807267 @default.
• W1513693864 cites W2052219197 @default.
• W1513693864 cites W2060449132 @default.
• W1513693864 cites W2063247432 @default.
• W1513693864 cites W2065572938 @default.
• W1513693864 cites W2067690445 @default.
• W1513693864 cites W2071410302 @default.
• W1513693864 cites W2073908835 @default.
• W1513693864 cites W2077570593 @default.
• W1513693864 cites W2083822658 @default.
• W1513693864 cites W2098638123 @default.
• W1513693864 cites W2102533478 @default.
• W1513693864 cites W2105749810 @default.
• W1513693864 cites W2118654016 @default.
• W1513693864 cites W2130293973 @default.
• W1513693864 cites W2142918811 @default.
• W1513693864 cites W2158253639 @default.
• W1513693864 cites W2160698607 @default.
• W1513693864 cites W2164083842 @default.
• W1513693864 cites W2167956058 @default.
• W1513693864 cites W4322696863 @default.
• W1513693864 cites W89521975 @default.
• W1513693864 doi "https://doi.org/10.1111/wrr.12238" @default.
• W1513693864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4304906" @default.
• W1513693864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25327261" @default.
• W1513693864 hasPublicationYear "2014" @default.
• W1513693864 type Work @default.
• W1513693864 sameAs 1513693864 @default.
• W1513693864 citedByCount "30" @default.
• W1513693864 countsByYear W15136938642015 @default.
• W1513693864 countsByYear W15136938642016 @default.
• W1513693864 countsByYear W15136938642017 @default.
• W1513693864 countsByYear W15136938642018 @default.
• W1513693864 countsByYear W15136938642019 @default.
• W1513693864 countsByYear W15136938642020 @default.
• W1513693864 countsByYear W15136938642021 @default.
• W1513693864 countsByYear W15136938642022 @default.
• W1513693864 countsByYear W15136938642023 @default.
• W1513693864 crossrefType "journal-article" @default.
• W1513693864 hasAuthorship W1513693864A5008685812 @default.
• W1513693864 hasAuthorship W1513693864A5010311645 @default.
• W1513693864 hasAuthorship W1513693864A5011291680 @default.
• W1513693864 hasAuthorship W1513693864A5026452682 @default.
• W1513693864 hasAuthorship W1513693864A5027795357 @default.
• W1513693864 hasAuthorship W1513693864A5027852438 @default.
• W1513693864 hasAuthorship W1513693864A5028402841 @default.
• W1513693864 hasAuthorship W1513693864A5028626094 @default.
• W1513693864 hasAuthorship W1513693864A5035544818 @default.
• W1513693864 hasAuthorship W1513693864A5038629120 @default.
• W1513693864 hasAuthorship W1513693864A5050822671 @default.
• W1513693864 hasAuthorship W1513693864A5059973732 @default.
• W1513693864 hasAuthorship W1513693864A5066964238 @default.
• W1513693864 hasBestOaLocation W15136938641 @default.

• next