FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1513845439> ?p ?o ?g. }

• W1513845439 endingPage "87" @default.
• W1513845439 startingPage "371" @default.
• W1513845439 abstract "To present a clinical approach to the management of acute asthma and the life threatening episode of asthma.A review of published peer-review articles and studies reported from 1966 to 1999 and identified through a MEDLINE search on the management of acute asthma, status asthmaticus and acute fulminant asthma.Asthma is a disease caused by a chronic desquamative eosinophilic bronchitis with airway hyper-responsiveness to specific and non-specific stimuli. It is characterised clinically by episodic airflow obstruction. A life threatening episode indicates the presence of one of the three clinical types; acute severe asthma (an acute episode of bronchospasm where the FEV(1) is 30% or less than the predicted value), status asthmaticus (where the episode becomes resistant to beta-adrenergic agonists and corticosteroids), or acute fulminant asthma (where the onset is rapid and severe and the patient is obtunded). Management of acute severe asthma includes oxygen, continuous nebulised salbutamol (until an adequate clinical response occurs) and intravenous hydrocortisone (200 mg/70 kg i.v. followed by 50 mg/70 kg hourly or 200 mg 4-hourly). The patient's speech, conscious state, pulse and respiratory rate, peak expiratory flow rate, oximetry and blood gases should be monitored, and if there is no improvement or the patient deteriorates, admission to an intensive care unit is required. Additional therapy includes intravenous aminophylline (2mg/kg, followed by 4 mg/kg over 30 minutes), nebulised ipratropium (500 microg 6-hourly), high dose inhaled corticosteroids, intravenous magnesium sulphate (5-10 mmol as a bolus with 40 mmol over 1-2 hours), and even inhaled helium oxygen mixtures. With further deterioration or for the management of acute fulminant asthma, intravenous adrenaline (20-200microg bolus followed by an infusion of 1-10 microg/min) is often used. Endotracheal intubation, with mechanical ventilation (using low tidal volumes and low respiratory rates) ketamine anaesthesia (1-2 mg/kg followed by 50 microg/kg/min), inhaled anaesthetic agents (e.g. diethyl ether) and even extracoporeal life support (using extracorporeal membrane oxygenation) may be required.Inhaled salbutamol and intravenous corticosteroids are initially administered to manage the episode of acute severe asthma. Management of acute fulminant asthma or status asthmaticus requires admission to the intensive care unit and may require anaesthetic agents and complex life support techniques." @default.
• W1513845439 created "2016-06-24" @default.
• W1513845439 creator A5008290765 @default.
• W1513845439 creator A5008665663 @default.
• W1513845439 date "1999-12-01" @default.
• W1513845439 modified "2023-09-23" @default.
• W1513845439 title "Acute asthma and the life threatening episode." @default.
• W1513845439 cites W1519406897 @default.
• W1513845439 cites W1528786455 @default.
• W1513845439 cites W161411377 @default.
• W1513845439 cites W164805863 @default.
• W1513845439 cites W1662552754 @default.
• W1513845439 cites W175985133 @default.
• W1513845439 cites W1785644247 @default.
• W1513845439 cites W1884410677 @default.
• W1513845439 cites W1904035648 @default.
• W1513845439 cites W1908062287 @default.
• W1513845439 cites W1911142559 @default.
• W1513845439 cites W1942883321 @default.
• W1513845439 cites W1944466828 @default.
• W1513845439 cites W1964126342 @default.
• W1513845439 cites W1965813295 @default.
• W1513845439 cites W1966545653 @default.
• W1513845439 cites W1968393659 @default.
• W1513845439 cites W1971720272 @default.
• W1513845439 cites W1972892226 @default.
• W1513845439 cites W1974218242 @default.
• W1513845439 cites W1974777512 @default.
• W1513845439 cites W1975551935 @default.
• W1513845439 cites W1976021567 @default.
• W1513845439 cites W1976693346 @default.
• W1513845439 cites W1978177449 @default.
• W1513845439 cites W1978189323 @default.
• W1513845439 cites W1979349548 @default.
• W1513845439 cites W1980244389 @default.
• W1513845439 cites W1980333713 @default.
• W1513845439 cites W1981037875 @default.
• W1513845439 cites W1981965384 @default.
• W1513845439 cites W1984719540 @default.
• W1513845439 cites W1986774655 @default.
• W1513845439 cites W1987704448 @default.
• W1513845439 cites W1990951259 @default.
• W1513845439 cites W1991857563 @default.
• W1513845439 cites W1992874758 @default.
• W1513845439 cites W1994508688 @default.
• W1513845439 cites W1994745317 @default.
• W1513845439 cites W1994821895 @default.
• W1513845439 cites W1995632888 @default.
• W1513845439 cites W1996232332 @default.
• W1513845439 cites W1996326192 @default.
• W1513845439 cites W1996920248 @default.
• W1513845439 cites W2004754060 @default.
• W1513845439 cites W2006297837 @default.
• W1513845439 cites W2006358731 @default.
• W1513845439 cites W2007998500 @default.
• W1513845439 cites W2009485602 @default.
• W1513845439 cites W2009791320 @default.
• W1513845439 cites W2009899847 @default.
• W1513845439 cites W2010560046 @default.
• W1513845439 cites W2011063575 @default.
• W1513845439 cites W2011109887 @default.
• W1513845439 cites W2011234828 @default.
• W1513845439 cites W2011286935 @default.
• W1513845439 cites W2011642310 @default.
• W1513845439 cites W2012066935 @default.
• W1513845439 cites W2014399257 @default.
• W1513845439 cites W2016709676 @default.
• W1513845439 cites W2018505166 @default.
• W1513845439 cites W2018702279 @default.
• W1513845439 cites W2020716977 @default.
• W1513845439 cites W2023179519 @default.
• W1513845439 cites W2024005207 @default.
• W1513845439 cites W2024436875 @default.
• W1513845439 cites W2026934822 @default.
• W1513845439 cites W2028450080 @default.
• W1513845439 cites W2029251290 @default.
• W1513845439 cites W2030838568 @default.
• W1513845439 cites W2032205757 @default.
• W1513845439 cites W2032499666 @default.
• W1513845439 cites W2039594179 @default.
• W1513845439 cites W2039907207 @default.
• W1513845439 cites W2040915400 @default.
• W1513845439 cites W2045660738 @default.
• W1513845439 cites W2048329856 @default.
• W1513845439 cites W2049125017 @default.
• W1513845439 cites W2049576537 @default.
• W1513845439 cites W2050378424 @default.
• W1513845439 cites W2051845643 @default.
• W1513845439 cites W2052912371 @default.
• W1513845439 cites W2056892304 @default.
• W1513845439 cites W2057904383 @default.
• W1513845439 cites W2059818497 @default.
• W1513845439 cites W2062190353 @default.
• W1513845439 cites W2062997585 @default.
• W1513845439 cites W2065719831 @default.
• W1513845439 cites W2066154844 @default.
• W1513845439 cites W2066254634 @default.
• W1513845439 cites W2066350149 @default.

• next