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- W1513872519 abstract "This chapter analyzes oxygen-dependent regulation of pulmonary circulation. The central function of the lung is to oxygenate the blood. To carry out this task, an extensive capillary network branches through alveolar structures to create an alveolar surface area. The lung has to rapidly adapt its perfusion and circulation patterns to keep the proper oxygenation of the blood to an optimum level. Central to this regulation is the matching of pulmonary blood flow to areas of varying ventilation accordingly to match the local ventilation—that is, the precapillary pulmonary arteries can contract or dilate accordingly to match the local levels of alveolar oxygen. In this chapter, chronic hypoxic models are discussed along with their pathobiological significance. Oxygen regulation of pulmonary circulation in the neonate, pulmonary vascular morphology and morphometry, and chronic hypoxia models of pulmonary hypertension (PH) are described. The chapter discusses right ventricular hypertrophy, pulmonary artery hemodynamics, the gene chip array, the isolated perfused lung system, . .. the strategy for validation of array results for individual genes, and advances in expression profiling in human diseases." @default.
- W1513872519 created "2016-06-24" @default.
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- W1513872519 date "2004-01-01" @default.
- W1513872519 modified "2023-09-23" @default.
- W1513872519 title "Oxygen-Dependent Regulation of Pulmonary Circulation" @default.
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- W1513872519 doi "https://doi.org/10.1016/s0076-6879(04)81005-x" @default.
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