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- W1514042479 abstract "Ofloxacin, a newer broad-spectrum fluoroquinolone, was evaluated against >12,000 clinical isolates in a multicenter surveillance trial in the United States and Canada using the standardized disk diffusion method. A total of 53 geographically diverse clinical microbiology laboratories contributed zone diameter results for ofloxacin, ciprofloxacin, and norfloxacin for urinary tract infection (UTI) isolates; and ofloxacin and ciprofloxacin for respiratory tract infection (RTI) isolates, skin and soft tissue infection (SSTI) isolattes, and genital tract pathogen isolates. In both the USA and Canada, ofloxacin was shown to have the wide spectrum of activity as follows: RTI isolates, ofloxacin (92.2%–93.8% susceptible) >ciprofloxacin (89.5/2t- 90.4%); SST isolates, ofloxacin (87.1–933.6) > ciprofloxacin (78.8%–90.4%); UTI isolates, ofloxacin (91.6%–92.5%) > norfloxacin (87.3–81.7%) > ciprofloxacin (86.4%– 89.7%); and genital tract isolates, ofloxacin (94.0%) > ciprofloxacin (85.4%) (canada only). US strains resistant to ofloxacin were confirmed by reference, other than among staphylococci or nonenteric bacilli, was rare. The species most often found to be resistant to both ofloxacin and ciprofloxacin were methicillin-resistant staphylocci, Acinetobacter spp., and Enterococcus." @default.
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- W1514042479 title "North American (United States and Canada) comparative susceptibility of two fluoroquinolones: ofloxacin and ciprofloxacin" @default.
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- W1514042479 doi "https://doi.org/10.1016/0732-8893(94)90133-3" @default.
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