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- W151410145 abstract "We explored the protective effect of varying doses of the antioxidant quercetin on mitochondrial function in C57BL/6J mice on a high fat (HF) diet. Six week old male C57BL/6J mice (N = 192) were randomly assigned to one of the following diets: HF (45% kcal fat), HF + 600ug quercetin/day (600Q), HF + 250ug quercetin/day (250Q) or HF + 50ug quercetin/day (50Q). Body weight (BW), body composition (BC), and food consumption (FC) were measured weekly. At 3 weeks (wk) and 8 wk, energy expenditure (EE), respiratory exchange ratio (RER), and activity were assessed. At the 3 and 8wk time points, animals were sacrificed and quadriceps muscle was used for quantification of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1α) mRNA by real time PCR. The assessed variables did not differ at 3 wk, but at 8 wk 50Q significantly increased EE (P < 0.05) but did not change PGC1α Conversely, the 600Q group exhibited a decrease in EE yet higher levels of PGC1α in comparison to HF (P < 0.05). 250Q had no difference in EE at 8 wk but increased PGC1α (P < 0.05). There were no differences in BW, BC, or FC among groups at 8wk. We conclude that 8wk of quercetin supplementation causes dose-related metabolic responses that may be indicative of protective mitochondrial adaptations to a HF diet, independent of a reduction in BW or a change in BC. Grant Funding Source: Botanical Research Pilot Funding Program - Pennington Biomedical Research Center" @default.
- W151410145 created "2016-06-24" @default.
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- W151410145 date "2010-04-01" @default.
- W151410145 modified "2023-10-01" @default.
- W151410145 title "Quercetin causes dose‐related increases in energy expenditure and PGC1α in muscle of C57BL/6J mice" @default.
- W151410145 doi "https://doi.org/10.1096/fasebj.24.1_supplement.540.15" @default.
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