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- W1514171421 abstract "Publisher Summary This chapter examines in vivo effects of interferon (IFN) suppression of the natural killer (NK) target structure. The TS modulation can occur in vivo and that this may reduce the effectiveness of the hosts' NK response to tumor. The study described in the chapter examines this hypothesis using an NK-sensitive clone of the SL2 lymphoma, which proved to be exquisitely responsive to the membrane modulating effects of IFN. Incubation of the tumor with as little as 10 U/ml of L cell IFN for 20 hours prior to exposure to NK cells reduced lysis by over 60% of control. This inhibition appeared to be a result of loss of the NK target structure because the IFN reduced the capacity of unlabeled tumor to inhibit the lysis of labeled target cells. The sensitivity to IFN in vitro was reflected in the behavior of the tumor in vivo . Significant slowing of the elimination of 131-IUdR labeled SL2 from the peritoneal cavity was observed when tumor was incubated with 10–100 U/ml of IFN for 20 h in vitro . Reduction in elimination rate could best be demonstrated in young (6–7 week) mice." @default.
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- W1514171421 date "1982-01-01" @default.
- W1514171421 modified "2023-09-27" @default.
- W1514171421 title "THE IN VIVO EFFECTS OF INTERFERON (IFN) SUPPRESSION OF THE NK TARGET STRUCTURE" @default.
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- W1514171421 doi "https://doi.org/10.1016/b978-0-12-341360-4.50204-3" @default.
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