FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514200939> ?p ?o ?g. }

• W1514200939 endingPage "1597" @default.
• W1514200939 startingPage "1592" @default.
• W1514200939 abstract "OBJECTIVE To investigate the effects of chronic ethanol consumption and diabetes on nitric oxide (NO)‐mediated relaxation of cavernosal smooth muscle (CSM). MATERIAL AND METHODS Male Wistar rats were divided into four groups: control, isocaloric, diabetic and ethanol‐diabetic. The CSMs were mounted in organ chambers for measurement of isometric tension. Contraction of the strips was induced by electrical field stimulation (EFS, 1–32 Hz) and phenylephrine. We also evaluated the effect of ethanol consumption on the relaxation induced by acetylcholine (ACh; 0.01–1000 µmol/L), sodium nitroprusside (SNP, 0.01–1000 µmol/L) or EFS (1–32 Hz) in strips pre‐contracted with phenylephrine (10 µmol/L). Immunoexpression of endothelial NO synthase (eNOS) and inducible NOS (iNOS) was also accessed. RESULTS The endothelium‐dependent relaxation induced by ACh was decreased in CSM from ethanol‐diabetic rats when compared with the controls, with a mean ( sem ) of 21 (4) vs 37 (2)%. Similarly, the potency and maximal responses induced by SNP were reduced in the ethanol‐diabetic [3.97 (0.38) and 85 (1)%, respectively] and diabetic groups [3.78 (0.56) and 81 (2)%, respectively] when compared with the controls [5.3 (0.22) and 90 (3)%, respectively] and isocaloric [5.3 (0.19) and 92 (1)%, respectively] groups. Noradrenergic nerve‐mediated contractions of CSM in response to EFS were increased in rats from ethanol‐diabetic and diabetic groups when compared with the control and isocaloric groups. Conversely, there were no differences in EFS‐induced relaxation among the groups. The immunostaining assays showed overexpression of eNOS and iNOS in the CSM from diabetic and ethanol‐diabetic rats when compared with the control and isocaloric rats. CONCLUSION There was an impairment of relaxation of CSM from ethanol‐diabetic and diabetic rats that involved a decrease in the NO‐cyclic guanosine monophosphate signalling pathway by endothelium‐dependent mechanisms accompanied by a change in the CSM contractile sensitivity." @default.
• W1514200939 created "2016-06-24" @default.
• W1514200939 creator A5001673304 @default.
• W1514200939 creator A5011899509 @default.
• W1514200939 creator A5014363434 @default.
• W1514200939 creator A5017189284 @default.
• W1514200939 creator A5024998572 @default.
• W1514200939 creator A5035140285 @default.
• W1514200939 creator A5041617090 @default.
• W1514200939 creator A5046349000 @default.
• W1514200939 creator A5056971177 @default.
• W1514200939 creator A5063793574 @default.
• W1514200939 creator A5065600437 @default.
• W1514200939 creator A5078188829 @default.
• W1514200939 creator A5081419236 @default.
• W1514200939 creator A5084376049 @default.
• W1514200939 creator A5091009354 @default.
• W1514200939 date "2010-05-10" @default.
• W1514200939 modified "2023-10-17" @default.
• W1514200939 title "Chronic alcoholism associated with diabetes impairs erectile function in rats" @default.
• W1514200939 cites W1836107361 @default.
• W1514200939 cites W1971398565 @default.
• W1514200939 cites W2004710613 @default.
• W1514200939 cites W2009705599 @default.
• W1514200939 cites W2010626606 @default.
• W1514200939 cites W2012365138 @default.
• W1514200939 cites W2022901952 @default.
• W1514200939 cites W2023517378 @default.
• W1514200939 cites W2065393771 @default.
• W1514200939 cites W2068433760 @default.
• W1514200939 cites W2102138984 @default.
• W1514200939 cites W2148091278 @default.
• W1514200939 cites W2164631329 @default.
• W1514200939 cites W2179702494 @default.
• W1514200939 cites W2414780834 @default.
• W1514200939 doi "https://doi.org/10.1111/j.1464-410x.2009.09084.x" @default.
• W1514200939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20132198" @default.
• W1514200939 hasPublicationYear "2010" @default.
• W1514200939 type Work @default.
• W1514200939 sameAs 1514200939 @default.
• W1514200939 citedByCount "11" @default.
• W1514200939 countsByYear W15142009392014 @default.
• W1514200939 countsByYear W15142009392015 @default.
• W1514200939 countsByYear W15142009392017 @default.
• W1514200939 countsByYear W15142009392018 @default.
• W1514200939 countsByYear W15142009392020 @default.
• W1514200939 countsByYear W15142009392021 @default.
• W1514200939 crossrefType "journal-article" @default.
• W1514200939 hasAuthorship W1514200939A5001673304 @default.
• W1514200939 hasAuthorship W1514200939A5011899509 @default.
• W1514200939 hasAuthorship W1514200939A5014363434 @default.
• W1514200939 hasAuthorship W1514200939A5017189284 @default.
• W1514200939 hasAuthorship W1514200939A5024998572 @default.
• W1514200939 hasAuthorship W1514200939A5035140285 @default.
• W1514200939 hasAuthorship W1514200939A5041617090 @default.
• W1514200939 hasAuthorship W1514200939A5046349000 @default.
• W1514200939 hasAuthorship W1514200939A5056971177 @default.
• W1514200939 hasAuthorship W1514200939A5063793574 @default.
• W1514200939 hasAuthorship W1514200939A5065600437 @default.
• W1514200939 hasAuthorship W1514200939A5078188829 @default.
• W1514200939 hasAuthorship W1514200939A5081419236 @default.
• W1514200939 hasAuthorship W1514200939A5084376049 @default.
• W1514200939 hasAuthorship W1514200939A5091009354 @default.
• W1514200939 hasConcept C103486182 @default.
• W1514200939 hasConcept C126322002 @default.
• W1514200939 hasConcept C134018914 @default.
• W1514200939 hasConcept C163415756 @default.
• W1514200939 hasConcept C185592680 @default.
• W1514200939 hasConcept C2775910092 @default.
• W1514200939 hasConcept C2777622882 @default.
• W1514200939 hasConcept C2777952589 @default.
• W1514200939 hasConcept C2778326061 @default.
• W1514200939 hasConcept C2779610285 @default.
• W1514200939 hasConcept C2779929075 @default.
• W1514200939 hasConcept C2780161600 @default.
• W1514200939 hasConcept C519581460 @default.
• W1514200939 hasConcept C55493867 @default.
• W1514200939 hasConcept C555293320 @default.
• W1514200939 hasConcept C71924100 @default.
• W1514200939 hasConcept C84393581 @default.
• W1514200939 hasConceptScore W1514200939C103486182 @default.
• W1514200939 hasConceptScore W1514200939C126322002 @default.
• W1514200939 hasConceptScore W1514200939C134018914 @default.
• W1514200939 hasConceptScore W1514200939C163415756 @default.
• W1514200939 hasConceptScore W1514200939C185592680 @default.
• W1514200939 hasConceptScore W1514200939C2775910092 @default.
• W1514200939 hasConceptScore W1514200939C2777622882 @default.
• W1514200939 hasConceptScore W1514200939C2777952589 @default.
• W1514200939 hasConceptScore W1514200939C2778326061 @default.
• W1514200939 hasConceptScore W1514200939C2779610285 @default.
• W1514200939 hasConceptScore W1514200939C2779929075 @default.
• W1514200939 hasConceptScore W1514200939C2780161600 @default.
• W1514200939 hasConceptScore W1514200939C519581460 @default.
• W1514200939 hasConceptScore W1514200939C55493867 @default.
• W1514200939 hasConceptScore W1514200939C555293320 @default.
• W1514200939 hasConceptScore W1514200939C71924100 @default.
• W1514200939 hasConceptScore W1514200939C84393581 @default.
• W1514200939 hasIssue "11" @default.

• next