Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514219782> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1514219782 endingPage "1021" @default.
- W1514219782 startingPage "1017" @default.
- W1514219782 abstract "Listeria monocytogenes is one of several Gram-positive bacteria known to contain an auxiliary ATPase (SecA2) involved in the Sec secretion of a subset of proteins important to bacterial pathogenesis, including autolysins. It is not known if IspC, a novel surface-associated autolysin essential for full virulence of L. monocytogenes serotype 4b, is SecA2-dependent for secretion. By creating a secA2 gene deletion (ΔsecA2) mutant from the wild type (WT) L. monocytogenes serotype 4b strain, in combination with the proteomic analysis of surface proteins and those secreted into the medium from both the mutant and the WT, we confirmed previous findings that two autolysins (p60 and NamA) are SecA2-dependent for secretion. However, this approach did not identify IspC as one of the surface proteins affected by the SecA2 deletion. Further experiments with immunofluorescence microscopy and Western blotting indicated that IspC was well displayed on the surface of both the ΔsecA2 mutant and WT cells, while p60 was not, clearly indicating that the secretion of IspC is not attributed to the SecA2 pathway. This finding sets IspC apart from other autolysins involved in virulence, such as p60 and NamA, in that SecA2 is not required for IspC secretion." @default.
- W1514219782 created "2016-06-24" @default.
- W1514219782 creator A5040475616 @default.
- W1514219782 creator A5043689231 @default.
- W1514219782 creator A5057536396 @default.
- W1514219782 creator A5061123296 @default.
- W1514219782 date "2013-05-26" @default.
- W1514219782 modified "2023-09-23" @default.
- W1514219782 title "SecA2 is not required for secretion of the surface autolysin IspC inListeria monocytogenesserotype 4b" @default.
- W1514219782 cites W1821737407 @default.
- W1514219782 cites W1978639077 @default.
- W1514219782 cites W2000110235 @default.
- W1514219782 cites W2035295085 @default.
- W1514219782 cites W2046417457 @default.
- W1514219782 cites W2071212473 @default.
- W1514219782 cites W2078594804 @default.
- W1514219782 cites W2090495509 @default.
- W1514219782 cites W2099384916 @default.
- W1514219782 cites W2101830323 @default.
- W1514219782 cites W2104124603 @default.
- W1514219782 cites W2107993914 @default.
- W1514219782 cites W2113336105 @default.
- W1514219782 cites W2129634192 @default.
- W1514219782 cites W2133884021 @default.
- W1514219782 cites W2136163749 @default.
- W1514219782 cites W2163137725 @default.
- W1514219782 cites W2165465840 @default.
- W1514219782 cites W2167198550 @default.
- W1514219782 doi "https://doi.org/10.1002/jobm.201300007" @default.
- W1514219782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23712923" @default.
- W1514219782 hasPublicationYear "2013" @default.
- W1514219782 type Work @default.
- W1514219782 sameAs 1514219782 @default.
- W1514219782 citedByCount "0" @default.
- W1514219782 crossrefType "journal-article" @default.
- W1514219782 hasAuthorship W1514219782A5040475616 @default.
- W1514219782 hasAuthorship W1514219782A5043689231 @default.
- W1514219782 hasAuthorship W1514219782A5057536396 @default.
- W1514219782 hasAuthorship W1514219782A5061123296 @default.
- W1514219782 hasConcept C104317684 @default.
- W1514219782 hasConcept C143065580 @default.
- W1514219782 hasConcept C153911025 @default.
- W1514219782 hasConcept C2776809874 @default.
- W1514219782 hasConcept C49039625 @default.
- W1514219782 hasConcept C55493867 @default.
- W1514219782 hasConcept C60987743 @default.
- W1514219782 hasConcept C86803240 @default.
- W1514219782 hasConcept C95444343 @default.
- W1514219782 hasConceptScore W1514219782C104317684 @default.
- W1514219782 hasConceptScore W1514219782C143065580 @default.
- W1514219782 hasConceptScore W1514219782C153911025 @default.
- W1514219782 hasConceptScore W1514219782C2776809874 @default.
- W1514219782 hasConceptScore W1514219782C49039625 @default.
- W1514219782 hasConceptScore W1514219782C55493867 @default.
- W1514219782 hasConceptScore W1514219782C60987743 @default.
- W1514219782 hasConceptScore W1514219782C86803240 @default.
- W1514219782 hasConceptScore W1514219782C95444343 @default.
- W1514219782 hasIssue "9" @default.
- W1514219782 hasLocation W15142197821 @default.
- W1514219782 hasLocation W15142197822 @default.
- W1514219782 hasOpenAccess W1514219782 @default.
- W1514219782 hasPrimaryLocation W15142197821 @default.
- W1514219782 hasRelatedWork W1991260321 @default.
- W1514219782 hasRelatedWork W2020416941 @default.
- W1514219782 hasRelatedWork W2024180691 @default.
- W1514219782 hasRelatedWork W2050562599 @default.
- W1514219782 hasRelatedWork W2078846038 @default.
- W1514219782 hasRelatedWork W2122868133 @default.
- W1514219782 hasRelatedWork W2148070420 @default.
- W1514219782 hasRelatedWork W2731392871 @default.
- W1514219782 hasRelatedWork W2914415623 @default.
- W1514219782 hasRelatedWork W3193465640 @default.
- W1514219782 hasVolume "54" @default.
- W1514219782 isParatext "false" @default.
- W1514219782 isRetracted "false" @default.
- W1514219782 magId "1514219782" @default.
- W1514219782 workType "article" @default.